Vitamin E-loaded bigels and emulsions: Physicochemical characterization and potential biological application

[Display omitted] •Oil-in-water bigels and emulsions with interface crystallization pattern.•Bigels and emulsions with high thermal and centrifuge-stress stability.•Weak gels with higher thixotropy and consistency of 12-hydroxystearic bigels.•Vitamin E increased diameter of the inner phase of bigels...

Full description

Saved in:
Bibliographic Details
Published in:Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2021-05, Vol.201, p.111651-111651, Article 111651
Main Authors: Martinez, Renata Miliani, Magalhães, Wagner Vidal, Sufi, Bianca da Silva, Padovani, Giovana, Nazato, Lucas Idacir Sbrugnera, Velasco, Maria Valéria Robles, Lannes, Suzana Caetano da Silva, Baby, André Rolim
Format: Article
Language:English
Subjects:
12-hydroxystearic
Bigel
Candelilla wax
Organogel
Rheology
Stability
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:[Display omitted] •Oil-in-water bigels and emulsions with interface crystallization pattern.•Bigels and emulsions with high thermal and centrifuge-stress stability.•Weak gels with higher thixotropy and consistency of 12-hydroxystearic bigels.•Vitamin E increased diameter of the inner phase of bigels and emulsions.•Vitamin E increased gel strength and consistency in 12-hydroxystearic bigels. Bigels have been studied as topical formulations for its benefits over sensory and drug delivery parameters. However, there is still few evidences about the properties of the combination of organogelators, oily phases and bioactive molecules into rheological and stability behavior. We investigated the use of classical organogelators (candelilla wax and 12-hydroxystearic acid) and oily phases (sunflower and mineral oil) in 5/95 organogel/polymeric hydrogel ratio to compare vitamin E bigels with its corresponding emulsions. The rheological measurements, microstructure, physical and oxidative stability properties and biological behavior were evaluated. The obtained oil-in-water bigels and emulsions showed crystallization pattern at the interface with high thermal and centrifuge-stress stability. Viscoelastic weak gels were obtained with higher thixotropy and consistency of 12-hydroxystearic bigels. The diameter of the inner phase was increased by vitamin E, despite its little influence over physical and oxidative stability of bigels and emulsions. Those findings indicated that sensory attributes may be regulated by the organogel composition.
ISSN:0927-7765
1873-4367
DOI:10.1016/j.colsurfb.2021.111651