Recombinant human lactoferrin attenuates the progression of hepatosteatosis and hepatocellular death by regulating iron and lipid homeostasis in ob / ob mice

Lactoferrin (Lf), an iron-binding glycoprotein, has been shown to possess antioxidant and anti-inflammatory properties and exert modulatory effects on lipid homeostasis and non-alcoholic fatty liver disease (NAFLD), but our understanding of its regulatory mechanisms is limited and inconsistent. We u...

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Published in:	Food & function 2020-08, Vol.11 (8), p.7183-7196
Main Authors:	Guo, Chuang, Xue, Han, Guo, Tian, Zhang, Wei, Xuan, Wen-Qiang, Ren, Yan-Tao, Wang, Di, Chen, Yan-Hong, Meng, Yu-Han, Gao, Hui-Ling, Zhao, Pu
Format:	Article
Language:	English
Subjects:	Animal models Animals anti-inflammatory activity Anti-inflammatory agents Antioxidants Antioxidants - pharmacology Autophagy Autophagy - drug effects Body weight Cation Transport Proteins - metabolism Cell Death - drug effects Chemical compounds Cryoprotective Agents - pharmacology death Disease Models, Animal Disease Progression Down-Regulation - drug effects Endoplasmic reticulum Endoplasmic Reticulum Stress - drug effects Fatty liver Glycoproteins Growth factors Hemostasis - drug effects Hepatocytes Hepatocytes - drug effects hepatoprotective effect Hepcidin Hepcidins - metabolism Homeostasis Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Inflammation Injections, Intraperitoneal Insulin insulin resistance intraperitoneal injection Iron Iron - metabolism Lactoferrin Lactoferrin - pharmacology Leptin Lipid metabolism Lipid Metabolism - drug effects Lipids Liver Liver diseases liver function Mice Non-alcoholic Fatty Liver Disease - drug therapy Non-alcoholic Fatty Liver Disease - etiology Non-alcoholic Fatty Liver Disease - metabolism Phagocytosis Pharmacology Recombinant Proteins - pharmacology Regulatory mechanisms (biology) Steatosis Sterol Regulatory Element Binding Protein 2 - metabolism Sterol regulatory element-binding protein sterols therapeutics Up-Regulation - drug effects Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism
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