The Utility of Imaging Parameters in Predicting Long-Term Clinical Improvement After Shunt Surgery in Patients with Idiopathic Normal Pressure Hydrocephalus

• Published in: World neurosurgery 2021-05, Vol.149, p.e1-e10
• Main Authors: Subramanian, Harry E., Fadel, Sandra A., Matouk, Charles C., Zohrabian, Vahe M., Mahajan, Amit
• Format: Article
• Language: English
• Subjects: DESH; Disproportionately enlarged subarachnoid space hydrocephalus; Evans index; Idiopathic normal pressure hydrocephalus; iNPH; MRI; Outcome; Ventriculoperitoneal shunt
• ISSN: 1878-8750; 1878-8769
• DOI: 10.1016/j.wneu.2021.02.108

It is difficult to predict which patients with idiopathic normal pressure hydrocephalus (iNPH) will improve after shunt surgery. This study investigated the association between preoperative imaging parameters in patients with iNPH and long-term outcome after shunt placement. Patients with iNPH who showed a response to large-volume cerebrospinal fluid drainage and subsequently underwent ventriculoperitoneal shunt surgery were reviewed. Long-term patient-reported outcomes were obtained by telephone interview. Preoperative computed tomography and/or magnetic resonance imaging were retrospectively reviewed to determine associations between imaging parameters and clinical outcome. The final analysis included 37 patients. The median duration between shunt surgery and telephone interview was 30 months (range, 12–56 months). Gait improvement after shunting was present more often in patients without focally dilated sulci (95% vs. 71%, P = 0.04), but a statistically significant relationship was not established after logistic regression. Patients with cognitive improvement after shunting had a higher preoperative Evans index (mean 0.41 vs. 0.36, P < 0.01), and Evans index was a predictor of cognitive improvement (odds ratio = 1.40, scale of 0.01, P = 0.01). Higher Evans index is a predictor of long-term cognitive improvement after shunt placement; however, no cutoff value demonstrates sufficient accuracy for the selection of shunt candidates. None of the evaluated imaging features was predictive of long-term gait or urinary improvement. The utility of imaging to predict a response to shunting is limited, and no imaging feature alone can be used to exclude patients from shunt surgery.