Association between Patellofemoral and medial Tibiofemoral compartment osteoarthritis progression: exploring the effect of body weight using longitudinal data from osteoarthritis initiative (OAI)

• Published in: Skeletal radiology 2021-09, Vol.50 (9), p.1845-1854
• Main Authors: Pishgar, Farhad, Guermazi, Ali, Ashraf-ganjouei, Amir, Haj-Mirzaian, Arya, Roemer, Frank W., Zikria, Bashir, Sereni, Christopher, Hakky, Michael, Demehri, Shadpour
• Format: Article
• Language: English
• Subjects: Alignment; Arthritis; Biomarkers; Biomedical materials; Body mass index; Body size; Body weight; Consortia; Development and progression; Evaluation; Imaging; Magnetic resonance imaging; Medicine; Medicine & Public Health; Nuclear Medicine; Obesity; Orthopedics; Osteoarthritis; Overweight; Pain; Pathology; Quality; Radiology; Regression analysis; Regression models; Scientific Article
• ISSN: 0364-2348; 1432-2161
• DOI: 10.1007/s00256-021-03749-0

Objectives To investigate the associations of medial and lateral patellofemoral osteoarthritis (PF-OA) at baseline with symptomatic and radiographic OA outcomes in the medial tibiofemoral compartment (MTFC) over 4 years, according to baseline overweight status. Methods Data and MRI images of 600 subjects in the FNIH-OA biomarkers consortium were used. Symptomatic worsening and radiographic progression of MTFC-OA were defined using Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain scores and MTFC joint space narrowing (JSN) from baseline to 4-year follow-up. Baseline MRIs were read to establish PF-OA diagnosis. The association between baseline regional PF-OA pattern and odds for MTFC-OA progression was evaluated using regression models (adjusted for relevant confounding covariates including body mass index (BMI), age, sex, PF alignment measurements, KL grade, and knee alignment). To evaluate the effect modifying role for overweight status, stratification analysis was performed (BMI ≥ 25 vs.