Combined liver kidney transplantation for primary hyperoxaluria type 1: Will there still be a future? Current transplantation strategies and monocentric experience

• Published in: Pediatric transplantation 2021-06, Vol.25 (4), p.e14003-n/a
• Main Authors: Tandoi, Francesco, Cussa, Davide, Peruzzi, Licia, Catalano, Silvia, Camilla, Roberta, Mandrile, Giorgia, Calvo, Pier Luigi, Pinon, Michele, Dell’Olio, Dominic, Salizzoni, Mauro, Amoroso, Antonio, Romagnoli, Renato
• Format: Article
• Language: English
• Subjects: Adolescent; Child; Child, Preschool; Children; Female; Follow-Up Studies; Graft rejection; Graft Survival; Grafts; Hemodialysis; Humans; Hyperoxaluria; Hyperoxaluria, Primary - surgery; Infant; Kaplan-Meier Estimate; Kidney transplantation; Kidney Transplantation - methods; Kidney transplants; Liver; Liver diseases; Liver transplantation; Liver Transplantation - methods; Liver transplants; Logistic Models; Male; Oxalic acid; pediatric kidney transplantation; pediatric liver transplantation; Pediatrics; Perfusion; Primary hyperoxaluria; Primary hyperoxaluria type 1; Renal failure; Renal function; Retrospective Studies; Transplants & implants; Treatment Outcome
• ISSN: 1397-3142; 1399-3046
• DOI: 10.1111/petr.14003

Combined liver–kidney transplantation is a therapeutic option for children affected by type 1 primary hyperoxaluria. Persistently high plasma oxalate levels may lead to kidney graft failure. It is debated whether pre‐emptive liver transplantation, followed by kidney transplantation, might be a better strategy to reduce kidney graft loss. Our experience of 6 pediatric combined liver–kidney transplants for primary hyperoxaluria type 1 in pediatric recipients was retrospectively analyzed. Plasma oxalate levels were monitored before and after transplantation. All the recipients were on hemodialysis at transplantation. Median [IQR] recipient's age at transplantation was 11 [1–14] years; in all cases, a compatible graft from a pediatric brain‐dead donor aged 8 [2–16] years was used. In a median follow‐up of 7 [2–19] years after combined liver–kidney transplantation, no child died and no liver graft failure was observed; three kidney grafts were lost, due to chronic rejection, primary non‐function, and early renal oxalate accumulation. Liver and kidney graft survival remained stable at 1, 3, and 5 years, at 100% and 85%, respectively. Kidney graft loss was the major complication in our series. Risk is higher with very young, low‐weight donors. The impact of treatment with glyoxalate pathway enzyme inhibitors treatment in children with advanced disease as well as of donor kidney preservation by ex vivo machine perfusion needs to be evaluated. At present, a case‐by‐case discussion is needed to establish an optimal treatment strategy.