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Prevalence and risk factors of overweight and obesity in Chinese patients with first-episode drug-naïve major depressive disorder
•To the best of our knowledge, it is the first study to explore the prevalence of obesity/overweight and related risk factors in first-episode, drug-naïve (FEDN) patients with MDD in China.•Exploring the possible link between BMI and TSH, HAMD as well as inflammatory factors in FEDN patients with MD...
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| Published in: | Journal of affective disorders 2021-05, Vol.286, p.351-359 |
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| container_title | Journal of affective disorders |
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| creator | Si, Tong Yang, Kun Lang, XiaoE Dong, Xinglu Wang, Ningqun Zhang, Xiangyang Qu, Miao |
| description | •To the best of our knowledge, it is the first study to explore the prevalence of obesity/overweight and related risk factors in first-episode, drug-naïve (FEDN) patients with MDD in China.•Exploring the possible link between BMI and TSH, HAMD as well as inflammatory factors in FEDN patients with MDD.•Providing related clinical implications and possible mechanisms from the perspective of neuroendocrine and neuroimmune.
Obesity and overweight are common in patients with major depressive disorder (MDD); the results are inconsistent due to confounding variables involved in studies. Furthermore, no well-designed study has been published to investigate the prevalence, risk factors and underlying mechanisms of obesity/overweight in Chinese MDD patients. This study aimed to investigate the prevalence of obesity/overweight and related risk factors in first-episode, drug-naïve (FEDN) patients with MDD in China.
A total of 1718 patients were recruited. Their clinical and anthropometric data, thyroid function and biochemical parameters were collected. All patients were evaluated on the 17-item Hamilton Rating Scale for Depression, 14-item Hamilton Anxiety Rating Scale and the Positive and Negative Syndrome Scale.
The prevalence of obesity and overweight was 3.73% and 56.00%, respectively. Multivariable logistic regression analysis showed that TSH was the only independent risk factor for weight gain in MDD patents. The fitting curve of the relationship between TSH and BMI formed an inverted U-shaped parabola. The ordinal logit mode showed that when TSH |
| doi_str_mv | 10.1016/j.jad.2021.01.037 |
| format | article |
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Obesity and overweight are common in patients with major depressive disorder (MDD); the results are inconsistent due to confounding variables involved in studies. Furthermore, no well-designed study has been published to investigate the prevalence, risk factors and underlying mechanisms of obesity/overweight in Chinese MDD patients. This study aimed to investigate the prevalence of obesity/overweight and related risk factors in first-episode, drug-naïve (FEDN) patients with MDD in China.
A total of 1718 patients were recruited. Their clinical and anthropometric data, thyroid function and biochemical parameters were collected. All patients were evaluated on the 17-item Hamilton Rating Scale for Depression, 14-item Hamilton Anxiety Rating Scale and the Positive and Negative Syndrome Scale.
The prevalence of obesity and overweight was 3.73% and 56.00%, respectively. Multivariable logistic regression analysis showed that TSH was the only independent risk factor for weight gain in MDD patents. The fitting curve of the relationship between TSH and BMI formed an inverted U-shaped parabola. The ordinal logit mode showed that when TSH<=2.68 was set as a reference, the odd rates of weight increased with the increase of TSH, and the highest rate was 3.929 (95%CI: 2.879–5.361, P<0.0001).
Causality cannot be drawn due to cross-sectional design.
Our results suggest that overweight is very common among patients with FEDN MDD rather than obesity. TSH is a promising predictor and potential biomarker of high weight in MDD patients, and there is an inverted U-shaped parabolic relationship between TSH and BMI.</description><identifier>ISSN: 0165-0327</identifier><identifier>EISSN: 1573-2517</identifier><identifier>DOI: 10.1016/j.jad.2021.01.037</identifier><identifier>PMID: 33757648</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>China - epidemiology ; Cross-Sectional Studies ; Depressive Disorder, Major - epidemiology ; Humans ; Major depressive disorder ; Obesity ; Obesity - epidemiology ; Overweight ; Overweight - epidemiology ; Pharmaceutical Preparations ; Prevalence ; Risk Factors ; Thyroid stimulating hormone</subject><ispartof>Journal of affective disorders, 2021-05, Vol.286, p.351-359</ispartof><rights>2021 Elsevier B.V.</rights><rights>Copyright © 2021 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c268t-c3cbbf5bc7642c1a4f9759191f90a3bf680154f2029134a91687d62d750a59903</citedby><cites>FETCH-LOGICAL-c268t-c3cbbf5bc7642c1a4f9759191f90a3bf680154f2029134a91687d62d750a59903</cites><orcidid>0000-0001-6289-9654</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33757648$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Si, Tong</creatorcontrib><creatorcontrib>Yang, Kun</creatorcontrib><creatorcontrib>Lang, XiaoE</creatorcontrib><creatorcontrib>Dong, Xinglu</creatorcontrib><creatorcontrib>Wang, Ningqun</creatorcontrib><creatorcontrib>Zhang, Xiangyang</creatorcontrib><creatorcontrib>Qu, Miao</creatorcontrib><title>Prevalence and risk factors of overweight and obesity in Chinese patients with first-episode drug-naïve major depressive disorder</title><title>Journal of affective disorders</title><addtitle>J Affect Disord</addtitle><description>•To the best of our knowledge, it is the first study to explore the prevalence of obesity/overweight and related risk factors in first-episode, drug-naïve (FEDN) patients with MDD in China.•Exploring the possible link between BMI and TSH, HAMD as well as inflammatory factors in FEDN patients with MDD.•Providing related clinical implications and possible mechanisms from the perspective of neuroendocrine and neuroimmune.
Obesity and overweight are common in patients with major depressive disorder (MDD); the results are inconsistent due to confounding variables involved in studies. Furthermore, no well-designed study has been published to investigate the prevalence, risk factors and underlying mechanisms of obesity/overweight in Chinese MDD patients. This study aimed to investigate the prevalence of obesity/overweight and related risk factors in first-episode, drug-naïve (FEDN) patients with MDD in China.
A total of 1718 patients were recruited. Their clinical and anthropometric data, thyroid function and biochemical parameters were collected. All patients were evaluated on the 17-item Hamilton Rating Scale for Depression, 14-item Hamilton Anxiety Rating Scale and the Positive and Negative Syndrome Scale.
The prevalence of obesity and overweight was 3.73% and 56.00%, respectively. Multivariable logistic regression analysis showed that TSH was the only independent risk factor for weight gain in MDD patents. The fitting curve of the relationship between TSH and BMI formed an inverted U-shaped parabola. The ordinal logit mode showed that when TSH<=2.68 was set as a reference, the odd rates of weight increased with the increase of TSH, and the highest rate was 3.929 (95%CI: 2.879–5.361, P<0.0001).
Causality cannot be drawn due to cross-sectional design.
Our results suggest that overweight is very common among patients with FEDN MDD rather than obesity. TSH is a promising predictor and potential biomarker of high weight in MDD patients, and there is an inverted U-shaped parabolic relationship between TSH and BMI.</description><subject>China - epidemiology</subject><subject>Cross-Sectional Studies</subject><subject>Depressive Disorder, Major - epidemiology</subject><subject>Humans</subject><subject>Major depressive disorder</subject><subject>Obesity</subject><subject>Obesity - epidemiology</subject><subject>Overweight</subject><subject>Overweight - epidemiology</subject><subject>Pharmaceutical Preparations</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>Thyroid stimulating hormone</subject><issn>0165-0327</issn><issn>1573-2517</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kMGKFDEQhoMo7rj6AF4kRy89Jp1Op4MnGdQVFvSg55BOKjtpZzptKjPLXn0hH8IX24yzehQKCipf_VQ-Ql5ytuaM92-m9WT9umUtX7NaQj0iKy6VaFrJ1WOyqoxsmGjVBXmGODHGeq3YU3IhhJKq74YV-fklw9HuYHZA7expjvidButKykhToOkI-Rbizbb8eU4jYCx3NM50s40zINDFlghzQXoby5aGmLE0sERMHqjPh5tmtr9_HYHu7ZQy9bBkQIx14CuTPeTn5EmwO4QXD_2SfPvw_uvmqrn-_PHT5t1149p-KI0TbhyDHF09vHXcdkErqbnmQTMrxtAPjMsuVBuai85q3g_K961XklmpNROX5PU5d8npxwGwmH1EB7udnSEd0LSSdUopOXQV5WfU5YSYIZglx73Nd4Yzc1JvJlPVm5N6w2oJVXdePcQfxj34fxt_XVfg7RmA-sljhGzQxZN4HzO4YnyK_4m_B5ezlmQ</recordid><startdate>20210501</startdate><enddate>20210501</enddate><creator>Si, Tong</creator><creator>Yang, Kun</creator><creator>Lang, XiaoE</creator><creator>Dong, Xinglu</creator><creator>Wang, Ningqun</creator><creator>Zhang, Xiangyang</creator><creator>Qu, Miao</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6289-9654</orcidid></search><sort><creationdate>20210501</creationdate><title>Prevalence and risk factors of overweight and obesity in Chinese patients with first-episode drug-naïve major depressive disorder</title><author>Si, Tong ; Yang, Kun ; Lang, XiaoE ; Dong, Xinglu ; Wang, Ningqun ; Zhang, Xiangyang ; Qu, Miao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c268t-c3cbbf5bc7642c1a4f9759191f90a3bf680154f2029134a91687d62d750a59903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>China - epidemiology</topic><topic>Cross-Sectional Studies</topic><topic>Depressive Disorder, Major - epidemiology</topic><topic>Humans</topic><topic>Major depressive disorder</topic><topic>Obesity</topic><topic>Obesity - epidemiology</topic><topic>Overweight</topic><topic>Overweight - epidemiology</topic><topic>Pharmaceutical Preparations</topic><topic>Prevalence</topic><topic>Risk Factors</topic><topic>Thyroid stimulating hormone</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Si, Tong</creatorcontrib><creatorcontrib>Yang, Kun</creatorcontrib><creatorcontrib>Lang, XiaoE</creatorcontrib><creatorcontrib>Dong, Xinglu</creatorcontrib><creatorcontrib>Wang, Ningqun</creatorcontrib><creatorcontrib>Zhang, Xiangyang</creatorcontrib><creatorcontrib>Qu, Miao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of affective disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Si, Tong</au><au>Yang, Kun</au><au>Lang, XiaoE</au><au>Dong, Xinglu</au><au>Wang, Ningqun</au><au>Zhang, Xiangyang</au><au>Qu, Miao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and risk factors of overweight and obesity in Chinese patients with first-episode drug-naïve major depressive disorder</atitle><jtitle>Journal of affective disorders</jtitle><addtitle>J Affect Disord</addtitle><date>2021-05-01</date><risdate>2021</risdate><volume>286</volume><spage>351</spage><epage>359</epage><pages>351-359</pages><issn>0165-0327</issn><eissn>1573-2517</eissn><abstract>•To the best of our knowledge, it is the first study to explore the prevalence of obesity/overweight and related risk factors in first-episode, drug-naïve (FEDN) patients with MDD in China.•Exploring the possible link between BMI and TSH, HAMD as well as inflammatory factors in FEDN patients with MDD.•Providing related clinical implications and possible mechanisms from the perspective of neuroendocrine and neuroimmune.
Obesity and overweight are common in patients with major depressive disorder (MDD); the results are inconsistent due to confounding variables involved in studies. Furthermore, no well-designed study has been published to investigate the prevalence, risk factors and underlying mechanisms of obesity/overweight in Chinese MDD patients. This study aimed to investigate the prevalence of obesity/overweight and related risk factors in first-episode, drug-naïve (FEDN) patients with MDD in China.
A total of 1718 patients were recruited. Their clinical and anthropometric data, thyroid function and biochemical parameters were collected. All patients were evaluated on the 17-item Hamilton Rating Scale for Depression, 14-item Hamilton Anxiety Rating Scale and the Positive and Negative Syndrome Scale.
The prevalence of obesity and overweight was 3.73% and 56.00%, respectively. Multivariable logistic regression analysis showed that TSH was the only independent risk factor for weight gain in MDD patents. The fitting curve of the relationship between TSH and BMI formed an inverted U-shaped parabola. The ordinal logit mode showed that when TSH<=2.68 was set as a reference, the odd rates of weight increased with the increase of TSH, and the highest rate was 3.929 (95%CI: 2.879–5.361, P<0.0001).
Causality cannot be drawn due to cross-sectional design.
Our results suggest that overweight is very common among patients with FEDN MDD rather than obesity. TSH is a promising predictor and potential biomarker of high weight in MDD patients, and there is an inverted U-shaped parabolic relationship between TSH and BMI.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>33757648</pmid><doi>10.1016/j.jad.2021.01.037</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-6289-9654</orcidid></addata></record> |
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| source | ScienceDirect Journals |
| subjects | China - epidemiology Cross-Sectional Studies Depressive Disorder, Major - epidemiology Humans Major depressive disorder Obesity Obesity - epidemiology Overweight Overweight - epidemiology Pharmaceutical Preparations Prevalence Risk Factors Thyroid stimulating hormone |
| title | Prevalence and risk factors of overweight and obesity in Chinese patients with first-episode drug-naïve major depressive disorder |
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