Value of the synovial C-reactive protein test in the diagnosis of total hip and knee periprosthetic joint infections: A case-control study

The diagnosis of periprosthetic joint infection (PJI) can be challenging and rests on several principles. The use of diagnostic biomarkers, such as the synovial C-Reactive Protein (CRP), seems promising. The purpose of this study was to determine whether synovial CRP was a more discriminating test t...

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Bibliographic Details
Published in:Orthopaedics & traumatology, surgery & research surgery & research, 2021-06, Vol.107 (4), p.102903-102903, Article 102903
Main Authors: Praz, César, Gubbiotti, Laura, Buia, Geoffrey, Chapus, Valentin, Dunet, Julien, Grandhomme, Frederique, Michon, Jocelyn, Rochcongar, Goulven, Hulet, Christophe
Format: Article
Language:English
Subjects:
Biomarkers of infection
Hip prosthesis
Knee prosthesis
Periprosthetic joint infection
Serum CRP
Synovial CRP
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Summary:The diagnosis of periprosthetic joint infection (PJI) can be challenging and rests on several principles. The use of diagnostic biomarkers, such as the synovial C-Reactive Protein (CRP), seems promising. The purpose of this study was to determine whether synovial CRP was a more discriminating test than serum CRP for the diagnosis of hip and knee PJI. In total, 194 patients were included in this single center prospective study: 42 primary arthroplasties (control group [CG]), 111 revisions for aseptic prosthesis (aseptic revision group [ARG]), and 41 revisions for septic prosthesis (septic revision group [SRG]) based on the Musculoskeletal Infection Society (MSIS) criteria. The serum and synovial CRP levels were significantly higher in the SRG than the other two groups (SRG serum CRP=75.6mg/L vs. ARG serum CRP=6mg/L and CG serum CRP=2.7mg/L, p
ISSN:1877-0568
1877-0568
DOI:10.1016/j.otsr.2021.102903