Cancer-related vulnerable lesions in patients with stable coronary artery disease

• Published in: International journal of cardiology 2021-07, Vol.335, p.1-6
• Main Authors: Taruya, Akira, Nakajima, Yuki, Tanaka, Atsushi, Kashiwagi, Manabu, Tanimoto, Takashi, Kuroi, Akio, Shiono, Yasutsugu, Shimamura, Kunihiro, Kubo, Takashi, Sougawa, Hiromichi, Masuno, Tomizo, Ozaki, Yuichi, Satogami, Keisuke, Ota, Shingo, Katayama, Yosuke, Ino, Yasushi, Hoshiya, Hironobu, Akasaka, Takashi
• Format: Article
• Language: English
• Subjects: Cancer; Coronary artery disease; Histology; Inflammation; Optical coherence tomography; Plaque rupture
• ISSN: 0167-5273; 1874-1754
• DOI: 10.1016/j.ijcard.2021.03.050

Coronary artery disease (CAD) has become a major cause of morbidity and mortality in cancer survivors. It is still unclear whether cancer history influences lesion characteristics. The purpose of this study was to investigate cancer-related lesion morphology in patients with CAD. This study enrolled 400 patients with stable CAD. The patients were classified into a cancer survivor group (n = 69) and a noncancer group (n = 331). We investigated coronary lesion morphology by optical coherence tomography, and we assessed the prognosis in terms of both all-cause mortality and major adverse cardiovascular events (MACE). Adenocarcinoma was the most common histopathological diagnosis. Serum C-reactive protein levels were significantly higher in the cancer survivor group than in the noncancer group (cancer survivors 0.12 [0.05–0.42] mg/dL vs. noncancer 0.08 [0.04–0.17] mg/dL, p = 0.019). The cancer survivor group was more likely than the noncancer group to have thrombi (cancer survivors 30.4% vs. noncancer 15.4%, p = 0.004), and layered fibrotic plaques (LFPs; cancer survivors 18.8% vs. noncancer 3.6%, p