Diagnostic and therapeutic values of PMEPA1 and its correlation with tumor immunity in pan-cancer

The prostate transmembrane protein, androgen induced 1 (PMEPA1) is differentially expressed in pan-cancer. However, PMEPA1 specific role in cancers has not been fully clarified. This study aims to explore the potential role of Pmepa1 in pan-cancer and specific cancer, with a view to deepening the re...

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Bibliographic Details
Published in:Life sciences (1973) 2021-07, Vol.277, p.119452-119452, Article 119452
Main Authors: Wang, Bin, Zhong, Jun-Long, Li, Hui-Zi, Wu, Biao, Sun, Di-Fang, Jiang, Ning, Shang, Jie, Chen, Yu-Feng, Xu, Xiang-He, Lu, Hua-Ding
Format: Article
Language:English
Subjects:
Adenocarcinoma
Cancer
Correlation
Drug development
Genes
Immune checkpoint
Immune system
Immunosuppressive agents
Infiltration
Language
Metastases
Microsatellite instability
Pan-cancer
Perl
PMEPA1
Prognosis
Prostate
Prostate cancer
TCGA
Therapeutic targets
Trifluoperazine
Tumor cells
Tumor immunity
Tumor microenvironment
Tumors
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Summary:The prostate transmembrane protein, androgen induced 1 (PMEPA1) is differentially expressed in pan-cancer. However, PMEPA1 specific role in cancers has not been fully clarified. This study aims to explore the potential role of Pmepa1 in pan-cancer and specific cancer, with a view to deepening the research on the pathological mechanism of cancer. The Perl language and R language were used to identify the correlation between PMEPA1 expression level and clinical indicators, prognosis values, tumor microenvironment, immune cells' infiltration, immune checkpoint genes, TMB and MSI. The Therapeutic Target Database was used for identifying potential therapeutic drugs that target the pathways that are significantly affected by PMEPA1 expression. PMEPA1 differential expression significantly correlated with patients' age, race, tumors' stage and status. PMEPA1 high expression was closely correlated with poor prognosis in many cancer types, excluding prostate adenocarcinoma. PMEPA1 expression was closely related to tumor cells and the immune microenvironment in stromal and immune cells' level, immune cells' infiltration, immune checkpoint genes, tumor mutational burden and microsatellite instability. We also found that the activity of the olfactory transduction pathway was closely related to PMEPA1 expression. In pan-cancer, Trifluoperazine and Halofantrine have the potential to reduce PMEPA1 expression. This study integrated existing data to explore PMEPA1 potential function in cancers, provided insights for the future cancer-related studies. [Display omitted]
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2021.119452