Atlas of breast cancer infiltrated B-lymphocytes revealed by paired single-cell RNA-sequencing and antigen receptor profiling

To gain mechanistic insights into the functions and developmental dynamics of tumor-infiltrated immune cells, especially B-lymphocytes, here we combine single-cell RNA-sequencing and antigen receptor lineage analysis to characterize a large number of triple-negative breast cancer infiltrated immune...

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Bibliographic Details
Published in:	Nature communications 2021-04, Vol.12 (1), p.2186-13, Article 2186
Main Authors:	Hu, Qingtao, Hong, Yu, Qi, Pan, Lu, Guangqing, Mai, Xueying, Xu, Sheng, He, Xiaoying, Guo, Yu, Gao, Linlin, Jing, Zhiyi, Wang, Jiawen, Cai, Tao, Zhang, Yu
Format:	Article
Language:	English
Subjects:	38 38/23 38/39 49/31 631/250/1619/40 631/250/2152/1566/2493 631/250/248 631/67/580 Aged Antigens Breast cancer Breast Neoplasms - blood Breast Neoplasms - genetics Breast Neoplasms - immunology Cell differentiation Class switching Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene sequencing Heterogeneity Humanities and Social Sciences Humans Immune response Immune system Immunoglobulin Heavy Chains - genetics Immunological memory Immunosurveillance Immunotherapy Kaplan-Meier Estimate Lymphocytes Lymphocytes B Lymphocytes, Tumor-Infiltrating - immunology Memory cells Microenvironments Middle Aged multidisciplinary Nucleotide sequence Pathogenesis Peripheral blood Populations Receptors Receptors, Antigen - metabolism Recombination Ribonucleic acid RNA Science Science (multidisciplinary) Sequence Analysis, RNA Single-Cell Analysis Subgroups Transcription Transcriptome - genetics Tumor microenvironment Tumors
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