Focused Ultrasound Mechanical Disruption of Ex Vivo Rat Tendon

Around 30 million tendon injuries occur annually in the U.S. costing \ 114 billion. Conservative therapies, like dry needling, promote healing in chronically injured tendons by inducing microdamage but have mixed success rates. Focused ultrasound (fUS) therapy can noninvasively fractionate tissues...

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Bibliographic Details
Published in:IEEE transactions on ultrasonics, ferroelectrics, and frequency control ferroelectrics, and frequency control, 2021-09, Vol.68 (9), p.2981-2986
Main Authors: Smallcomb, Molly, Elliott, Jacob, Khandare, Sujata, Butt, Ali A., Vidt, Meghan E., Simon, Julianna C.
Format: Article
Language:English
Subjects:
Achilles Tendon
Acoustics
Animals
Disruption
Focused ultrasound (fUS)
Fractionation
High-Intensity Focused Ultrasound Ablation
histology
Injuries
mechanical disruption
Medical treatment
Rats
tendinopathy
tendon
Tendon Injuries
Tendons
Transducers
Ultrasonic imaging
Wound Healing
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Summary:Around 30 million tendon injuries occur annually in the U.S. costing \ 114 billion. Conservative therapies, like dry needling, promote healing in chronically injured tendons by inducing microdamage but have mixed success rates. Focused ultrasound (fUS) therapy can noninvasively fractionate tissues through the creation, oscillation, and collapse of bubbles in a process termed histotripsy; however, highly collagenous tissues, like tendon, have shown resistance to mechanical fractionation. This study histologically evaluates whether fUS mechanical disruption is achievable in tendons. Ex vivo rat tendons (45 Achilles and 44 supraspinatus) were exposed to 1.5-MHz fUS operating with 0.1-10 ms pulses repeated at 1-100 Hz for 15-60 s with peak positive pressures
ISSN:0885-3010
1525-8955
DOI:10.1109/TUFFC.2021.3075375