Urban air pollution induces alterations in redox metabolism and mitochondrial dysfunction in mice brain cortex

Previous reports indicate that the central nervous system (CNS) is a target of air pollution, causing tissue damage and functional alterations. Oxidative stress and neuroinflammation have been pointed out as possible mechanisms mediating these effects. The aim of this work was to study the chronic e...

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Published in:Archives of biochemistry and biophysics 2021-06, Vol.704, p.108875-108875, Article 108875
Main Authors: Calabró, Valeria, Garcés, Mariana, Cáceres, Lourdes, Magnani, Natalia D., Marchini, Timoteo, Freire, Agustina, Vico, Tamara, Martinefski, Manuela, Vanasco, Virginia, Tripodi, Valeria, Berra, Alejandro, Alvarez, Silvia, Evelson, Pablo
Format: Article
Language:English
Subjects:
Air pollution
Brain cortex
Mitochondria
NADPH oxidase
Oxidative metabolism
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Summary:Previous reports indicate that the central nervous system (CNS) is a target of air pollution, causing tissue damage and functional alterations. Oxidative stress and neuroinflammation have been pointed out as possible mechanisms mediating these effects. The aim of this work was to study the chronic effects of urban air pollution on mice brain cortex, focusing on oxidative stress markers, and mitochondrial function. Male 8-week-old BALB/c mice were exposed to filtered air (FA, control) or urban air (UA) inside whole-body exposure chambers, located in a highly polluted area of Buenos Aires city, for up to 4 weeks. Glutathione levels, assessed as GSH/GSSG ratio, were decreased after 1 and 2 weeks of exposure to UA (45% and 25% respectively vs. FA; p 
ISSN:0003-9861
1096-0384
DOI:10.1016/j.abb.2021.108875