Does sodium oxybate inhibit brain dopamine release in humans? An exploratory neuroimaging study

• Published in: Human psychopharmacology 2021-09, Vol.36 (5), p.e2791-n/a
• Main Authors: Kish, Stephen J, O'Leary, Gerald, Mamelak, Mortimer, McCluskey, Tina, Warsh, Jerry J, Shapiro, Colin, Bies, Robert, Yu, Yifan, Pollock, Bruce, Tong, Junchao, Boileau, Isabelle
• Format: Article
• Language: English
• Subjects: Brain - diagnostic imaging; Brain - metabolism; Carbon Radioisotopes - metabolism; Corpus Striatum - metabolism; Dopamine; Dopamine - metabolism; Dopamine D2 receptors; Drowsiness; Drug abuse; GHB; Humans; Medical imaging; Narcolepsy; Neostriatum; Neuroimaging; Positron emission tomography; Raclopride; Sleep disorders; sodium oxybate; Sodium Oxybate - pharmacology; xyrem; γ‐hydroxybutyrate
• ISSN: 0885-6222; 1099-1077
• DOI: 10.1002/hup.2791

Objective To establish in an exploratory neuroimaging study whether γ‐hydroxybutyrate (sodium oxybate [SO]), a sedative, anti‐narcoleptic drug with abuse potential, transiently inhibits striatal dopamine release in the human. Methods Ten healthy participants (30 years; 6M, 4F) and one participant with narcolepsy received a baseline positron emission tomography scan of [C‐11]raclopride, a D2/3 dopamine receptor radioligand sensitive to dopamine occupancy, followed approximately one week later by an oral sedative 3g dose of SO and two [C‐11]raclopride scans (1 h, 7 h post SO). Plasma SO levels and drowsiness duration were assessed. Results No significant changes were detected in [C‐11]raclopride binding in striatum overall 1 or 7 h after SO, but a small non‐significant increase in [C‐11]raclopride binding, implying decreased dopamine occupancy, was noted in limbic striatal subdivision at one hour (+6.5%; p uncorrected = 0.045; +13.2%, narcolepsy participant), returning to baseline at 7 h. A positive correlation was observed between drowsiness duration and percent change in [C‐11]raclopride binding in limbic striatum (r = 0.73; p = 0.017). Conclusions We did not find evidence in this sample of human subjects of a robust striatal dopamine change, as was reported in non‐human primates. Our preliminary data, requiring extension, suggest that a 3g sedative SO dose might cause slight transient inhibition of dopamine release in limbic striatum.