Higher Cerebral Small Vessel Disease Burden in Patients with White Matter Recent Small Subcortical Infarcts

• Published in: Journal of stroke and cerebrovascular diseases 2021-07, Vol.30 (7), p.105824-105824, Article 105824
• Main Authors: Rudilosso, Salvatore, Mena, Luis, Esteller, Diana, Olivera, Marta, Mengual, Juan José, Montull, Caterina, Castrillo, Laura, Urra, Xabier, Gómez-Choco, Manuel
• Format: Article
• Language: English
• Subjects: Cerebral small vessel disease; Lacunar infarct; Recent small subcortical infarct; White matter hyperintensities
• ISSN: 1052-3057; 1532-8511
• DOI: 10.1016/j.jstrokecerebrovasdis.2021.105824

•RSSI are an acute manifestation of cerebral small vessel disease(CSVD).•Twenty-per-cent of RSSI are located in the centrum semiovale and corona radiata(CSO).•CSO RSSI are larger but cause milder clinical symptoms than RSSI in other locations.•CSO RSSI are more frequently associated with previous stroke and severe CSVD. Recent small subcortical infarcts (RSSI) are considered an acute manifestation of cerebral small vessel disease (CSVD). We assessed whether the topography of RSSI was related to CSVD markers on magnetic resonance imaging (MRI). We screened the local registries of two independent stroke centers in Catalonia and selected patients with a symptomatic RSSI on MRI performed during admission. RSSI location was classified into brainstem, supratentorial subcortical structures (SSS), and centrum semiovale (CSO) regions. Clinical variables, including vascular risk factors, were collected. Radiological markers of CSVD on MRI were evaluated individually and by means of the global CSVD burden score. The associations between each RSSI location and CSVD markers were studied in uni- and multivariate logistic regression analysis. Among 475 patients with RSSI, 152 (32%) had an infarct in the brainstem, 227 (48%) in SSS, and 96 (20%) in CSO region. The median CSVD burden score was 2 (IQR, 1–3). After adjusting for confounding factors, a RSSI in CSO was associated with higher periventricular and deep white matter hyperintensity scores [OR 1.64 (95% CI, 1.16–2.33), and OR 1.44 (95% CI, 1.07–1.93), respectively]. Higher CSVD burden score was positively associated with CSO [OR 1.48 (95% CI, 1.22–1.81)] and inversely associated with SSS [0.85 (95% CI, 0.72–0.99)] location after adjusting for relevant confounders. CSO RSSI were related to a higher burden of CSVD, particularly to white matter hyperintensities, compared to other RSSI locations. The pathophysiological significance of such findings should be investigated in the future with advanced neuroimaging techniques.