Structural basis of GABAB receptor–Gi protein coupling

G-protein-coupled receptors (GPCRs) have central roles in intercellular communication 1 , 2 . Structural studies have revealed how GPCRs can activate G proteins. However, whether this mechanism is conserved among all classes of GPCR remains unknown. Here we report the structure of the class-C hetero...

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Bibliographic Details
Published in:Nature (London) 2021-06, Vol.594 (7864), p.594-598
Main Authors: Shen, Cangsong, Mao, Chunyou, Xu, Chanjuan, Jin, Nan, Zhang, Huibing, Shen, Dan-Dan, Shen, Qingya, Wang, Xiaomei, Hou, Tingjun, Chen, Zhong, Rondard, Philippe, Pin, Jean-Philippe, Zhang, Yan, Liu, Jianfeng
Format: Article
Language:English
Subjects:
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Binding
Binding sites
Biochemistry, Molecular Biology
Cellular Biology
Domains
G protein-coupled receptors
Humanities and Social Sciences
Life Sciences
multidisciplinary
Proteins
Receptors
Science
Science (multidisciplinary)
Structural Biology
γ-Aminobutyric acid B receptors
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