High incidence of NMDAR encephalitis among Austronesians: A population-based study in Sabah, Malaysia

NMDAR encephalitis may be more common among non-Caucasians. A population-based study was conducted to estimate its incidence in Sabah, Malaysia, where the population consists predominantly of Austronesians (84%), and with a Chinese minority. Registries of NMDAR encephalitis at neurology referral cen...

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Bibliographic Details
Published in:Journal of neuroimmunology 2021-07, Vol.356, p.577584-577584, Article 577584
Main Authors: Wong, Chee Keong, Hor, Jyh Yung, Loo, Yin Pin, Heng, Hock Sin, Lee, Shirley, Perianen, Presaad Pillai, Ong, Sheila Ai Mei, Majawit, Elyssa Milus, Chang, Alison Yen Pin, Chia, Yuen Kang, Leite, M. Isabel
Format: Article
Language:English
Subjects:
Asia
Epidemiology
Incidence
NMDA receptor encephalitis
Population study
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Summary:NMDAR encephalitis may be more common among non-Caucasians. A population-based study was conducted to estimate its incidence in Sabah, Malaysia, where the population consists predominantly of Austronesians (84%), and with a Chinese minority. Registries of NMDAR encephalitis at neurology referral centers were reviewed for case ascertainment. The annual incidence was 2.29/million (Austronesians: 2.56/million, Chinese: 1.31/million). Among pediatric population, the incidence was: Austronesians: 3.63/million, Chinese: 2.59/million. Our study demonstrated a higher incidence of NMDAR encephalitis among Austronesians than the predominantly Caucasian populations in Europe (0.5–0.9/million; pediatric: 0.7–1.5/million). Racial and genetic factors may contribute to risks of developing NMDAR encephalitis. [Display omitted] •NMDAR encephalitis was observed to be more common among non-Caucasians.•High annual incidence (2.56/million) among Austronesians in Sabah, Malaysia.•In Sabah Austronesian pediatric population, the annual incidence was 3.63/million.•This was higher than in European populations (
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2021.577584