On the origin of BAG(3) and its consequences for an expansion of BAG3's role in protein homeostasis

The B‐cell CLL 2‐associated athanogene (BAG) protein family in general and BAG3, in particular, are pivotal elements of cellular protein homeostasis, with BAG3 playing a major role in macroautophagy. In particular, in the contexts of senescence and degeneration, BAG3 has exhibited an essential role...

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Bibliographic Details
Published in:Journal of cellular biochemistry 2022-01, Vol.123 (1), p.102-114
Main Authors: Baeken, Marius W., Behl, Christian
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing - chemistry
Adaptor Proteins, Signal Transducing - genetics
Adaptor Proteins, Signal Transducing - metabolism
Animals
Apoptosis Regulatory Proteins - chemistry
Apoptosis Regulatory Proteins - genetics
Apoptosis Regulatory Proteins - metabolism
autophagy
Autophagy - physiology
BAG3
Cellular Senescence - physiology
Chronic lymphocytic leukemia
Degeneration
Evolution, Molecular
Fungi - metabolism
Homeostasis
Humans
LIR domain
Phylogeny
Plants - metabolism
Proteasome Endopeptidase Complex - metabolism
Protein Domains
Proteins
Proteolysis
proteostasis
Proteostasis - physiology
Senescence
Signal Transduction - physiology
WW domain
Zebrafish
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Summary:The B‐cell CLL 2‐associated athanogene (BAG) protein family in general and BAG3, in particular, are pivotal elements of cellular protein homeostasis, with BAG3 playing a major role in macroautophagy. In particular, in the contexts of senescence and degeneration, BAG3 has exhibited an essential role often related to its capabilities to organize and remove aggregated proteins. Exciting studies in different species ranging from human, murine, zebrafish, and plant samples have delivered vital insights into BAG3s' (and other BAG proteins') functions and their regulations. However, so far no studies have addressed neither BAG3's evolution nor its phylogenetic position in the BAG family. In our here presented research, we were able to identify possible and highly conserved LC3 interacting region (LIR) motifs within the protein structure of BAG3. These revelations may cast a new light on BAG3's role in proteostasis and autophagy, independent of other receptor and adaptor proteins.
ISSN:0730-2312
1097-4644
DOI:10.1002/jcb.29925