Computational principles and challenges in single-cell data integration

The development of single-cell multimodal assays provides a powerful tool for investigating multiple dimensions of cellular heterogeneity, enabling new insights into development, tissue homeostasis and disease. A key challenge in the analysis of single-cell multimodal data is to devise appropriate s...

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Bibliographic Details
Published in:Nature biotechnology 2021-10, Vol.39 (10), p.1202-1215
Main Authors: Argelaguet, Ricard, Cuomo, Anna S. E., Stegle, Oliver, Marioni, John C.
Format: Article
Language:English
Subjects:
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631/553
Agriculture
Biochemical assays
Bioinformatics
Biomedical and Life Sciences
Biomedical Engineering/Biotechnology
Biomedicine
Biotechnology
Chromatin
Computer applications
Data integration
Datasets
Electronic data processing
Experiments
Genetic diversity
Genomes
Genomics
Heterogeneity
Homeostasis
Horizontal integration
Laboratories
Life Sciences
Medical research
Methods
Molecular biology
Principles
Review Article
Sensory integration
Transcription
Vertical integration
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