A Meta-analysis of Gut Microbiota in Children with Autism

Previous studies have reported dysbiosis in the gut microbiota (GM) of children with autism spectrum disorders (ASD), which may be a determining factor on child development through the microbiota-gut-brain axis. However, it is not clear if there is a specific group of dysbiotic bacteria in ASD. The...

Full description

Saved in:
Bibliographic Details
Published in:Journal of autism and developmental disorders 2022-03, Vol.52 (3), p.1374-1387
Main Authors: Andreo-Martínez, Pedro, Rubio-Aparicio, María, Sánchez-Meca, Julio, Veas, Alejandro, Martínez-González, Agustín Ernesto
Format: Article
Language:English
Subjects:
Autism
Autism Spectrum Disorder - microbiology
Autistic children
Autistic Disorder
Bacteria
Behavioral Science and Psychology
Bifidobacterium
Biochemistry
Child
Child and School Psychology
Child development
Children
Demographic aspects
Diagnosis
Dysbacteriosis
Dysbiosis
Dysbiosis - microbiology
Evaluation
Gastrointestinal Microbiome
Genetic engineering
Health aspects
Humans
Incidence
Intestinal microflora
Meta-analysis
Microbiology
Microbiota
Microbiota (Symbiotic organisms)
Neurosciences
Original Paper
Pediatrics
Pervasive Developmental Disorders
Physiology
Psychology
Public Health
Risk factors
Selection criteria
Streptococcus infections
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Previous studies have reported dysbiosis in the gut microbiota (GM) of children with autism spectrum disorders (ASD), which may be a determining factor on child development through the microbiota-gut-brain axis. However, it is not clear if there is a specific group of dysbiotic bacteria in ASD. The aim of this study was to carry out a meta-analysis on the studies that analyze GM in children with ASD. 18 studies fulfilled our selection criteria. Our results showed a lower relative abundance of Streptococcus ( SMD +  = − 0.999; 95% CI − 1.549, − 0.449) and Bifidobacterium genera ( SMD +  = − 0.513; 95% CI − 0.953, − 0.073) in children with ASD. Overall, the Bifidobacterium genera is involved. However, differences found between studies are attributed to factors such as reporting bias.
ISSN:0162-3257
1573-3432
DOI:10.1007/s10803-021-05002-y