Can non-cholesterol sterols indicate the presence of specific dysregulation of cholesterol metabolism in patients with colorectal cancer?

[Display omitted] Colorectal cancer (CRC) is a highly prevalent malignancy. Previous studies suggested that cholesterol might play a signficant role in malignant transformation and proliferation. Non-cholesterol sterols (NCS), which are transported by serum lipoproteins alongside cholesterol, are re...

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Published in:Biochemical pharmacology 2022-02, Vol.196, p.114595-114595, Article 114595
Main Authors: Vladimirov, Sandra, Gojkovic, Tamara, Zeljkovic, Aleksandra, Jelic-Ivanovic, Zorana, Zeljkovic, Dejan, Antonic, Tamara, Trifunovic, Bratislav, Spasojevic-Kalimanovska, Vesna
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - blood
Case-Control Studies
Cholesterol - blood
Cholesterol synthesis and absorption
Cohort Studies
Colorectal cancer
Colorectal Neoplasms - blood
Colorectal Neoplasms - diagnosis
Dyslipidemia
Female
HDL
Humans
Male
Middle Aged
Non-cholesterol sterols
Peripheral tissue
Sterols - blood
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Summary:[Display omitted] Colorectal cancer (CRC) is a highly prevalent malignancy. Previous studies suggested that cholesterol might play a signficant role in malignant transformation and proliferation. Non-cholesterol sterols (NCS), which are transported by serum lipoproteins alongside cholesterol, are regarded as cholesterol synthesis and absorption markers. Quantification of NCS in serum and HDL fraction (NCSHDL), could provide a better insight into the cholesterol metabolism. The aim of this study was to examine the status of cholesterol synthesis and cholesterol absorption markers in serum and HDL fraction and explore their interrelation in CRC patients. Current study was designed as observational, case-control study. The study included 73 CRC patients and 95 healthy subjects. NCS and NCSHDL concentrations were determined by HPLC-MS/MS. Based on NCS and NCSHDL concentrations, different cholesterol homeostasis indices were calculated. Patients had significantly lower NCS (P
ISSN:0006-2952
1873-2968
DOI:10.1016/j.bcp.2021.114595