A randomized controlled trial to evaluate omentum-preserving gastrectomy for patients with T1–T3 gastric cancer

Although complete omentectomy is traditionally performed in patients with gastric cancer as part of radical gastrectomy to ensure the elimination of micrometastases, the prognostic value of omentectomy during gastrectomy remains unclear. Retrospective studies have shown that the incidence of metasta...

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Bibliographic Details
Published in:Future oncology (London, England) England), 2021-09, Vol.17 (25), p.3301-3307
Main Authors: Lu, Sheng, Yang, Zhong-Yin, Yan, Chao, Liu, Wen-Tao, Ni, Zhen-Tian, Yao, Xue-Xin, Hua, Zi-Chen, Feng, Run-Hua, Zheng, Ya-Nan, Wang, Zhen-Qiang, Sah, Birendra Kumar, Chen, Ming-Min, Zhu, Zheng-Lun, He, Chang-Yu, Li, Chen, Yan, Min, Zhu, Zheng-Gang
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Disease-Free Survival
Female
gastrectomy
Gastrectomy - methods
Gastrectomy - statistics & numerical data
gastric cancer
greater omentum
Humans
Lymph Node Excision
Male
Middle Aged
Neoplasm Recurrence, Local - epidemiology
Neoplasm Recurrence, Local - prevention & control
Neoplasm Staging
omentectomy
Omentum - surgery
Organ Sparing Treatments - methods
Organ Sparing Treatments - statistics & numerical data
Prognosis
Prospective Studies
Randomized Controlled Trials as Topic
Retrospective Studies
Stomach Neoplasms - diagnosis
Stomach Neoplasms - mortality
Stomach Neoplasms - surgery
surgery
Survival Rate
Young Adult
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Description
Summary:Although complete omentectomy is traditionally performed in patients with gastric cancer as part of radical gastrectomy to ensure the elimination of micrometastases, the prognostic value of omentectomy during gastrectomy remains unclear. Retrospective studies have shown that the incidence of metastases in the greater omentum is very low in T1–T3 gastric cancer. Thus radical gastrectomy with D2 lymphadenectomy and preservation of the greater omentum may be a proper curative treatment for gastric cancer patients with T1–T3 tumors. The aim of this article is to describe the design and rationale for this prospective, randomized controlled DRAGON-05 trial, conducted to evaluate the prognostic value of omentum-preserving gastrectomy for patients with T1–T3 gastric cancer.  (ClinicalTrials.gov)
ISSN:1479-6694
1744-8301
DOI:10.2217/fon-2021-0240