High-Risk Morphological and Physiological Coronary Disease Attributes as Outcome Markers After Medical Treatment and Revascularization

This study sought to evaluate the prognostic impact of plaque morphology and coronary physiology on outcomes after medical treatment or percutaneous coronary intervention (PCI). Although fractional flow reserve (FFR) is currently best practice, morphological characteristics of coronary artery diseas...

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Published in:JACC. Cardiovascular imaging 2021-10, Vol.14 (10), p.1977-1989
Main Authors: Yang, Seokhun, Koo, Bon-Kwon, Hwang, Doyeon, Zhang, Jinlong, Hoshino, Masahiro, Lee, Joo Myung, Murai, Tadashi, Park, Jiesuck, Shin, Eun-Seok, Doh, Joon-Hyung, Nam, Chang-Wook, Wang, Jianan, Chen, Shaoliang, Tanaka, Nobuhiro, Matsuo, Hitoshi, Akasaka, Takashi, Chang, Hyuk-Jae, Kakuta, Tsunekazu, Narula, Jagat
Format: Article
Language:English
Subjects:
atherosclerosis
coronary artery disease
fractional flow reserve
lesion-specific ischemia
plaque characteristics
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Summary:This study sought to evaluate the prognostic impact of plaque morphology and coronary physiology on outcomes after medical treatment or percutaneous coronary intervention (PCI). Although fractional flow reserve (FFR) is currently best practice, morphological characteristics of coronary artery disease also contribute to outcomes. A total of 872 vessels in 538 patients were evaluated by invasive FFR and coronary computed tomography angiography. High-risk attributes (HRA) were defined as high-risk physiological attribute (invasive FFR ≤0.8) and high-risk morphological attributes including: 1) local plaque burden (minimum lumen area 
ISSN:1936-878X
1876-7591
DOI:10.1016/j.jcmg.2021.04.004