Chemoproteomics-based target profiling of sinomenine reveals multiple protein regulators of inflammation

Although sinomenine (SIN) has been used to treat several inflammation-related diseases in the clinic for decades, the detailed anti-inflammatory mechanism remains elusive. Here, we present a chemoproteomic study that supports a polypharmacological mode of action for SIN to inhibit inflammation. Nota...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2021-06, Vol.57 (48), p.5981-5984
Main Authors: Chen, Lianguo, Wang, Hong-jian, Ji, Teng-fei, Zhang, Chong-Jing
Format: Article
Language:English
Subjects:
Inflammation
Proteins
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Summary:Although sinomenine (SIN) has been used to treat several inflammation-related diseases in the clinic for decades, the detailed anti-inflammatory mechanism remains elusive. Here, we present a chemoproteomic study that supports a polypharmacological mode of action for SIN to inhibit inflammation. Notably, functional validation revealed multiple new protein regulators whose knockdown could significantly affect inflammation. Activity-based protein profiling (ABPP) of a natural inhibitor of inflammation revealed multiple protein regulators of inflammation.
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc01522b