Guided bone regeneration simultaneous with implant placement using bovine-derived xenograft with and without liquid platelet-rich fibrin: a randomized controlled clinical trial

Objective To assess augmentation success after guided bone regeneration (GBR) carried out simultaneously with implant placement using bovine-derived xenograft alone and in combination with liquid platelet-rich fibrin (liquid-PRF) . Methods This randomized controlled clinical trial was conducted on p...

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Bibliographic Details
Published in:Clinical oral investigations 2021-09, Vol.25 (9), p.5563-5575
Main Authors: Işık, Gözde, Özden Yüce, Meltem, Koçak-Topbaş, Nazan, Günbay, Tayfun
Format: Article
Language:English
Subjects:
Bone grafts
Bone growth
Bone implants
Bone loss
Bone surgery
Clinical trials
Computed tomography
Dentistry
Fibrin
Mandible
Mechanical loading
Medicine
Original Article
Patients
Platelets
Prostheses
Regeneration
Transplants & implants
Xenografts
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Summary:Objective To assess augmentation success after guided bone regeneration (GBR) carried out simultaneously with implant placement using bovine-derived xenograft alone and in combination with liquid platelet-rich fibrin (liquid-PRF) . Methods This randomized controlled clinical trial was conducted on patients with horizontal bone deficiency in the posterior regions of the mandible. After implant placement, GBR procedures were randomly performed using liquid-PRF-enriched bovine-derived xenograft (for the test group) and with bovine-derived xenograft alone (for the control group). To assess the change in augmentation thickness, the primary outcome of the study, cone beam computed tomography was carried out at the implant sites on completion and 6 months after surgery. The secondary outcomes were marginal bone level and implant survival rate at prosthetic delivery and at 6 months, 1 year, and 2 years follow-up after loading. The significance level was set at p
ISSN:1432-6981
1436-3771
DOI:10.1007/s00784-021-03987-5