Reduced coupling between cerebrospinal fluid flow and global brain activity is linked to Alzheimer disease–related pathology

The glymphatic system plays an important role in clearing the amyloid-β (Aβ) and tau proteins that are closely linked to Alzheimer disease (AD) pathology. Glymphatic clearance, as well as Aβ accumulation, is highly dependent on sleep, but the sleep-dependent driving forces behind cerebrospinal fluid...

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Bibliographic Details
Published in:PLoS biology 2021-06, Vol.19 (6), p.e3001233
Main Authors: Han, Feng, Chen, Jing, Belkin-Rosen, Aaron, Gu, Yameng, Luo, Liying, Buxton, Orfeu M., Liu, Xiao
Format: Article
Language:English
Subjects:
Alzheimer's disease
Alzheimers disease
Amyloid
Biology and Life Sciences
Brain
Brain mapping
Cerebrospinal fluid
Clearances
Cognitive ability
Coupling
Development and progression
Fluid dynamics
Fluid flow
Functional magnetic resonance imaging
Magnetic resonance imaging
Medical imaging
Medicine and Health Sciences
Metabolites
Neurodegenerative diseases
Neuroimaging
Pathogenesis
Pathology
Physical Sciences
Physiological aspects
Physiology
Research and Analysis Methods
Risk analysis
Risk factors
Short Reports
Sleep
Tau protein
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