Progress in sensorimotor neuroscience of schizophrenia spectrum disorders: Lessons learned and future directions

The number of neuroimaging studies on movement disorders, sensorimotor, and psychomotor functioning in schizophrenia spectrum disorders (SSD) has steadily increased over the last two decades. Accelerated by the addition of the “sensorimotor domain” to the Research Domain Criteria (RDoC) framework in...

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Published in:Progress in neuro-psychopharmacology & biological psychiatry 2021-12, Vol.111, p.110370-110370, Article 110370
Main Authors: Hirjak, Dusan, Meyer-Lindenberg, Andreas, Sambataro, Fabio, Fritze, Stefan, Kukovic, Jacqueline, Kubera, Katharina M., Wolf, Robert C.
Format: Article
Language:English
Subjects:
Cerebellum - physiopathology
Humans
Magnetic Resonance Imaging
Movement Disorders - physiopathology
MRI
Neural Pathways
Neuroimaging
Neurologic Examination
Neurosciences
Psychomotor
Psychomotor Performance - physiology
Psychosis
Psychotic Disorders - physiopathology
Schizophrenia - physiopathology
Schizophrenia spectrum disorders
Sensorimotor domain
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Summary:The number of neuroimaging studies on movement disorders, sensorimotor, and psychomotor functioning in schizophrenia spectrum disorders (SSD) has steadily increased over the last two decades. Accelerated by the addition of the “sensorimotor domain” to the Research Domain Criteria (RDoC) framework in January 2019, neuroscience research on the role of sensorimotor dysfunction in SSD has gained greater scientific and clinical relevance. To draw attention to recent rapid progress in the field, we performed a triennial systematic review (PubMed search from January 1st, 2018 through December 31st, 2020), in which we highlight recent neuroimaging findings and discuss methodological pitfalls as well as challenges for future research. The identified magnetic resonance imaging (MRI) studies suggest that sensorimotor abnormalities in SSD are related to cerebello-thalamo-cortico-cerebellar network dysfunction. Longitudinal and interventional studies highlight the translational potential of the sensorimotor domain as putative biomarkers for treatment response and as targets for non-invasive neurostimulation techniques in SSD. •Sensorimotor neuroscience is growing rapidly.•CTCC dysfunction might lead to sensorimotor abnormalities in SSD.•Sensorimotor neuroscience exhibits diagnostic and therapeutic relevance.
ISSN:0278-5846
1878-4216
DOI:10.1016/j.pnpbp.2021.110370