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The prevalence and functional characteristics of CrpP-like in Pseudomonas aeruginosa isolates from China
Modifying enzyme-CrpP and its variants reduced the MICs of fluoroquinolones in Pseudomonas aeruginosa . This study investigated the dissemination and functional characteristics of CrpP-like in P. aeruginosa from China. The positive rate of crpP -like genes in 228 P. aeruginosa was 25.4% (58/228), an...
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| Published in: | European journal of clinical microbiology & infectious diseases 2021-12, Vol.40 (12), p.2651-2656 |
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| Main Authors: | , , , , , , , , , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c375t-216ccc0eece6b5fc491480580c631fd419ddf046b10986e1696b8be64ac2defa3 |
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| cites | cdi_FETCH-LOGICAL-c375t-216ccc0eece6b5fc491480580c631fd419ddf046b10986e1696b8be64ac2defa3 |
| container_end_page | 2656 |
| container_issue | 12 |
| container_start_page | 2651 |
| container_title | European journal of clinical microbiology & infectious diseases |
| container_volume | 40 |
| creator | Xu, Ye Zhang, Ying Zheng, Xiangkuo Yu, Kaihang Sun, Yao Liao, Wenli Jia, Huaiyu Xu, Chunquan Zhou, Tieli Shen, Mo |
| description | Modifying enzyme-CrpP and its variants reduced the MICs of fluoroquinolones in
Pseudomonas aeruginosa
. This study investigated the dissemination and functional characteristics of CrpP-like in
P. aeruginosa
from China. The positive rate of
crpP
-like genes in 228
P. aeruginosa
was 25.4% (58/228), and 6 new
crpP
-like genes were determined. Transformation experiments showed that CrpP-like had a low effect on CIP and LEV susceptibility. The genetic of
crpP
-positive was diverse. Furthermore, the mean expression level of
crpP
was no statistical difference between fluoroquinolone-susceptible and -resistant group (
P
> 0.05). CrpP-like may not play a significant role in fluoroquinolone resistance in
P. aeruginosa
. |
| doi_str_mv | 10.1007/s10096-021-04287-2 |
| format | article |
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Pseudomonas aeruginosa
. This study investigated the dissemination and functional characteristics of CrpP-like in
P. aeruginosa
from China. The positive rate of
crpP
-like genes in 228
P. aeruginosa
was 25.4% (58/228), and 6 new
crpP
-like genes were determined. Transformation experiments showed that CrpP-like had a low effect on CIP and LEV susceptibility. The genetic of
crpP
-positive was diverse. Furthermore, the mean expression level of
crpP
was no statistical difference between fluoroquinolone-susceptible and -resistant group (
P
> 0.05). CrpP-like may not play a significant role in fluoroquinolone resistance in
P. aeruginosa
.</description><identifier>ISSN: 0934-9723</identifier><identifier>EISSN: 1435-4373</identifier><identifier>DOI: 10.1007/s10096-021-04287-2</identifier><identifier>PMID: 34097170</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Anti-Bacterial Agents - pharmacology ; Antibiotics ; Antimicrobial agents ; Bacterial Proteins - genetics ; Bacterial Proteins - metabolism ; Biomedical and Life Sciences ; Biomedicine ; Brief Report ; China ; Ciprofloxacin - pharmacology ; Enzymes ; Experiments ; Fluoroquinolones ; Genes ; Genetic diversity ; Genetic transformation ; Hospitals ; Humans ; Infectious diseases ; Internal Medicine ; Laboratories ; Medical Microbiology ; Microbial Sensitivity Tests ; Mutation ; Plasmids ; Pseudomonas aeruginosa ; Pseudomonas aeruginosa - drug effects ; Pseudomonas aeruginosa - enzymology ; Pseudomonas aeruginosa - genetics ; Pseudomonas aeruginosa - isolation & purification ; Pseudomonas Infections - microbiology</subject><ispartof>European journal of clinical microbiology & infectious diseases, 2021-12, Vol.40 (12), p.2651-2656</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-216ccc0eece6b5fc491480580c631fd419ddf046b10986e1696b8be64ac2defa3</citedby><cites>FETCH-LOGICAL-c375t-216ccc0eece6b5fc491480580c631fd419ddf046b10986e1696b8be64ac2defa3</cites><orcidid>0000-0002-2171-4710</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34097170$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Ye</creatorcontrib><creatorcontrib>Zhang, Ying</creatorcontrib><creatorcontrib>Zheng, Xiangkuo</creatorcontrib><creatorcontrib>Yu, Kaihang</creatorcontrib><creatorcontrib>Sun, Yao</creatorcontrib><creatorcontrib>Liao, Wenli</creatorcontrib><creatorcontrib>Jia, Huaiyu</creatorcontrib><creatorcontrib>Xu, Chunquan</creatorcontrib><creatorcontrib>Zhou, Tieli</creatorcontrib><creatorcontrib>Shen, Mo</creatorcontrib><title>The prevalence and functional characteristics of CrpP-like in Pseudomonas aeruginosa isolates from China</title><title>European journal of clinical microbiology & infectious diseases</title><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><description>Modifying enzyme-CrpP and its variants reduced the MICs of fluoroquinolones in
Pseudomonas aeruginosa
. This study investigated the dissemination and functional characteristics of CrpP-like in
P. aeruginosa
from China. The positive rate of
crpP
-like genes in 228
P. aeruginosa
was 25.4% (58/228), and 6 new
crpP
-like genes were determined. Transformation experiments showed that CrpP-like had a low effect on CIP and LEV susceptibility. The genetic of
crpP
-positive was diverse. Furthermore, the mean expression level of
crpP
was no statistical difference between fluoroquinolone-susceptible and -resistant group (
P
> 0.05). CrpP-like may not play a significant role in fluoroquinolone resistance in
P. aeruginosa
.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotics</subject><subject>Antimicrobial agents</subject><subject>Bacterial Proteins - genetics</subject><subject>Bacterial Proteins - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brief Report</subject><subject>China</subject><subject>Ciprofloxacin - pharmacology</subject><subject>Enzymes</subject><subject>Experiments</subject><subject>Fluoroquinolones</subject><subject>Genes</subject><subject>Genetic diversity</subject><subject>Genetic transformation</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Internal Medicine</subject><subject>Laboratories</subject><subject>Medical Microbiology</subject><subject>Microbial Sensitivity Tests</subject><subject>Mutation</subject><subject>Plasmids</subject><subject>Pseudomonas aeruginosa</subject><subject>Pseudomonas aeruginosa - drug effects</subject><subject>Pseudomonas aeruginosa - enzymology</subject><subject>Pseudomonas aeruginosa - genetics</subject><subject>Pseudomonas aeruginosa - isolation & purification</subject><subject>Pseudomonas Infections - microbiology</subject><issn>0934-9723</issn><issn>1435-4373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kT9vFDEQxS0EIpfAF6CILNHQOPjf2usyOgGJFIkUoba83nHOYde-2LuR-PZxuEAkCpqZYn7vjWYeQh8YPWOU6s-1VaMI5YxQyXtN-Cu0YVJ0RAotXqMNNUISo7k4Qse13tEm6rV-i46EpEYzTTdod7MDvC_w4CZIHrBLIw5r8kvMyU3Y71xxfoES6xJ9xTngbdlfkyn-BBwTvq6wjnlubMUOynobU64Ox5ont0DFoeQZb3cxuXfoTXBThffP_QT9-PrlZntBrr5_u9yeXxEvdLcQzpT3ngJ4UEMXvDRM9rTrqVeChVEyM46BSjUwanoFTBk19AMo6TwfIThxgj4dfPcl369QFzvH6mGaXIK8Vss70fwo6_uGfvwHvctraWc_UUZTJpjqGsUPlC-51gLB7kucXfllGbVPOdhDDrblYH_nYHkTnT5br8MM41_Jn8c3QByA2kbpFsrL7v_YPgLamJPl</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Xu, Ye</creator><creator>Zhang, Ying</creator><creator>Zheng, Xiangkuo</creator><creator>Yu, Kaihang</creator><creator>Sun, Yao</creator><creator>Liao, Wenli</creator><creator>Jia, Huaiyu</creator><creator>Xu, Chunquan</creator><creator>Zhou, Tieli</creator><creator>Shen, Mo</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2171-4710</orcidid></search><sort><creationdate>20211201</creationdate><title>The prevalence and functional characteristics of CrpP-like in Pseudomonas aeruginosa isolates from China</title><author>Xu, Ye ; Zhang, Ying ; Zheng, Xiangkuo ; Yu, Kaihang ; Sun, Yao ; Liao, Wenli ; Jia, Huaiyu ; Xu, Chunquan ; Zhou, Tieli ; Shen, Mo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-216ccc0eece6b5fc491480580c631fd419ddf046b10986e1696b8be64ac2defa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Anti-Bacterial Agents - 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Academic</collection><jtitle>European journal of clinical microbiology & infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Ye</au><au>Zhang, Ying</au><au>Zheng, Xiangkuo</au><au>Yu, Kaihang</au><au>Sun, Yao</au><au>Liao, Wenli</au><au>Jia, Huaiyu</au><au>Xu, Chunquan</au><au>Zhou, Tieli</au><au>Shen, Mo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The prevalence and functional characteristics of CrpP-like in Pseudomonas aeruginosa isolates from China</atitle><jtitle>European journal of clinical microbiology & infectious diseases</jtitle><stitle>Eur J Clin Microbiol Infect Dis</stitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><date>2021-12-01</date><risdate>2021</risdate><volume>40</volume><issue>12</issue><spage>2651</spage><epage>2656</epage><pages>2651-2656</pages><issn>0934-9723</issn><eissn>1435-4373</eissn><abstract>Modifying enzyme-CrpP and its variants reduced the MICs of fluoroquinolones in
Pseudomonas aeruginosa
. This study investigated the dissemination and functional characteristics of CrpP-like in
P. aeruginosa
from China. The positive rate of
crpP
-like genes in 228
P. aeruginosa
was 25.4% (58/228), and 6 new
crpP
-like genes were determined. Transformation experiments showed that CrpP-like had a low effect on CIP and LEV susceptibility. The genetic of
crpP
-positive was diverse. Furthermore, the mean expression level of
crpP
was no statistical difference between fluoroquinolone-susceptible and -resistant group (
P
> 0.05). CrpP-like may not play a significant role in fluoroquinolone resistance in
P. aeruginosa
.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34097170</pmid><doi>10.1007/s10096-021-04287-2</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-2171-4710</orcidid></addata></record> |
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| ispartof | European journal of clinical microbiology & infectious diseases, 2021-12, Vol.40 (12), p.2651-2656 |
| issn | 0934-9723 1435-4373 |
| language | eng |
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| subjects | Anti-Bacterial Agents - pharmacology Antibiotics Antimicrobial agents Bacterial Proteins - genetics Bacterial Proteins - metabolism Biomedical and Life Sciences Biomedicine Brief Report China Ciprofloxacin - pharmacology Enzymes Experiments Fluoroquinolones Genes Genetic diversity Genetic transformation Hospitals Humans Infectious diseases Internal Medicine Laboratories Medical Microbiology Microbial Sensitivity Tests Mutation Plasmids Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - enzymology Pseudomonas aeruginosa - genetics Pseudomonas aeruginosa - isolation & purification Pseudomonas Infections - microbiology |
| title | The prevalence and functional characteristics of CrpP-like in Pseudomonas aeruginosa isolates from China |
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