Core–Shell Nanozymes “Artificial Peroxidase”: Stability with Superior Catalytic Properties

• Published in: The journal of physical chemistry letters 2021-06, Vol.12 (23), p.5547-5551
• Main Authors: Karpova, Elena V, Shcherbacheva, Elizaveta V, Komkova, Maria A, Eliseev, Andrei A, Karyakin, Arkady A
• Format: Article
• Language: English
• Subjects: Physical Insights into Chemistry, Catalysis, and Interfaces
• ISSN: 1948-7185; 1948-7185
• DOI: 10.1021/acs.jpclett.1c01200

We report on the nanoparticles composed of the catalytically synthesized Prussian Blue (PB) core stabilized with the nickel hexacyanoferrate (NiHCF) shell. Catalyzing hydrogen peroxide reduction, the resulting nanozymes (ø = 66 nm) display catalytic rate constants, which for pyrogallol or ferrocyanide are, respectively, 25 and 35 times higher than those for peroxidase enzyme. After more than half a year of storage at a room temperature, the core–shell PB-NiHCF nanozymes retain both their size and physicochemical properties; such stability is unreachable for the enzymes. Being immobilized, core–shell PB-NiHCF nanozymes (ø = 45 nm) result in a hydrogen peroxide sensor with a sensitivity similar to that of the sensor based on sole PB nanoparticles. However, whereas the latter response in hard inactivating conditions (25 min in 1 mM H2O2) drops down to 7.5%, the PB-NiHCF nanozymes-based sensor retains >75% of initial sensitivity. Application of the core–shell PB-NiHCF nanozymes “artificial peroxidase” would obviously open new horizons in elaboration of anti-inflammatory drugs and (bio)­sensors.