Multiscale modeling of bone tissue mechanobiology

• Published in: Bone (New York, N.Y.) N.Y.), 2021-10, Vol.151, p.116032-116032, Article 116032
• Main Authors: García-Aznar, José Manuel, Nasello, Gabriele, Hervas-Raluy, Silvia, Pérez, María Ángeles, Gómez-Benito, María José
• Format: Article
• Language: English
• Subjects: Bone Mechanobiology; Computer simulations; Implant design; Mechano-driven bone regeneration; Multiscale modeling; Scaffold design
• ISSN: 8756-3282; 1873-2763
• DOI: 10.1016/j.bone.2021.116032

Mechanical environment has a crucial role in our organism at the different levels, ranging from cells to tissues and our own organs. This regulatory role is especially relevant for bones, given their importance as load-transmitting elements that allow the movement of our body as well as the protection of vital organs from load impacts. Therefore bone, as living tissue, is continuously adapting its properties, shape and repairing itself, being the mechanical loads one of the main regulatory stimuli that modulate this adaptive behavior. Here we review some key results of bone mechanobiology from computational models, describing the effect that changes associated to the mechanical environment induce in bone response, implant design and scaffold-driven bone regeneration. •Computer models revealed the mechanics role at multiple scales of bone architecture.•Bone regeneration is scale orchestrated to achieve mechanical competence.•Computer multiscale modeling is a competent strategy to study bone mechanobiology.•Combination of simulations and image analysis provides a useful tool for validation.•Novel numerical techniques are required to get more reliable multiscale models.