Assessment of biventricular function in patients with hepatopulmonary syndrome

Cardiac function impairment in the setting of hepatopulmonary syndrome (HPS) in patients with end stage liver disease remains an issue of debate. The current study evaluated possible correlations between HPS and biventricular systolic function in patients with decompensated cirrhosis. Consecutive li...

Full description

Saved in:
Bibliographic Details
Published in:The International Journal of Cardiovascular Imaging 2021-10, Vol.37 (10), p.2891-2900
Main Authors: Soulaidopoulos, Stergios, Vlachou, Maria, Cholongitas, Evangelos, Giannakoulas, George, Panagiotidis, Theofilos, Drakopoulou, Maria, Karvounis, Haralambos, Goulis, Ioannis
Format: Article
Language:English
Subjects:
Alveoli
Ascites
Blood pressure
Cardiac function
Cardiac Imaging
Cardiology
Cardiovascular disease
Cirrhosis
Echocardiography
Ejection fraction
Heart
Hepatitis B
Hepatitis C
Imaging
Laboratories
Liver
Liver cancer
Liver cirrhosis
Liver diseases
Liver transplantation
Magnetic resonance imaging
Medicine
Medicine & Public Health
Muscle contraction
Original Paper
Oxygen
Parameters
Patients
Pulmonary arteries
Radiology
Software
Statistical analysis
Transplantation
Vasodilation
Ventricle
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cardiac function impairment in the setting of hepatopulmonary syndrome (HPS) in patients with end stage liver disease remains an issue of debate. The current study evaluated possible correlations between HPS and biventricular systolic function in patients with decompensated cirrhosis. Consecutive liver transplantation candidates with stable decompensated cirrhosis were prospectively evaluated. HPS was defined as the presence of an elevated alveolar–arterial oxygen gradient and intrapulmonary vasodilatation, detected by contrast enhanced echocardiography. HPS severity was determined based on arterial blood oxygen pressure values, while shunt size was assessed with a semi-quantitative method. Demographic, clinical and laboratory parameters were also prospectively collected. In total, 130 patients (mean age 56.5, M/F: 94/36, MELD score 14.6 ± 5.6) were enrolled, of whom 45 (34.6%) fulfilled the criteria for HPS diagnosis (mild: 57.7%, moderate: 33.3%, severe 4.4% and very severe 4.4%). Significantly lower absolute left ventricular (LV) global longitudinal strain (GLS) values (− 21.6 ± 2.3 vs. − 22.6 ± 2.5%, p = 0.041) were measured in patients with HPS compared to cirrhotic patients without HPS, while there was no statistically significant difference regarding right ventricular GLS (− 22.1 ± 3.3 vs. − 23.2 ± 3.5%, p = 0.061) between the two groups. Lower LV ejection fraction values were also recorded in the HPS group (53.9 ± 3.5 vs. 56.3 ± 4.5%, p 
ISSN:1569-5794
1573-0743
1875-8312
DOI:10.1007/s10554-021-02260-w