Increased risk of eosinophilic esophagitis with poor environmental quality as measured by the Environmental Quality Index

• Published in: Diseases of the esophagus 2021-12, Vol.34 (12)
• Main Authors: Nance, D, Rappazzo, K M, Jensen, E T, Hoffman, K, Cotton, C C, Krajewski, A K, Turner, K O, Genta, R M, Lobdell, D T, Dellon, E S
• Format: Article
• Language: English
• Subjects: Case-Control Studies; Environmental Exposure - adverse effects; Eosinophilic Esophagitis - epidemiology; Eosinophilic Esophagitis - etiology; Humans; Odds Ratio; Prevalence; United States - epidemiology
• ISSN: 1120-8694; 1442-2050
• DOI: 10.1093/dote/doab041

Summary Geographic differences in eosinophilic esophagitis (EoE) prevalence suggest the possibility that environmental exposures contribute to EoE pathogenesis. We aimed to examine the association between environmental quality and risk of EoE, using the Environmental Quality Index (EQI), which provides quantification of environmental quality in five domains: air, land, water, built, and sociodemographic for all counties in the United States. To do this, we performed a case–control study in a large pathology database. EoE cases were defined by ≥15 eosinophils per high-power field with other pathologic diagnoses excluded; controls did not have EoE. The pathology data were geocoded and linked with the EQI by county of residence. Logistic regression was used to estimate odds ratio (OR and 95% confidence interval [CI]) of EoE with overall EQI and for each domain, after adjusting for sex, age, and proportion minority race or ethnicity at the county level (higher EQI score indicates worse environmental quality). Of 29,802 EoE cases and 593,329 controls analyzed, odds of EoE were highest in the worst quintile of EQI (OR 1.25; 95% CI: 1.04–1.50), which was largely explained by poor scores in the water domain (OR: 1.33; 1.17–1.50). Conversely, odds of EoE were reduced with higher scores in the air domain (OR: 0.87, 0.74–1.03) and land domain (OR 0.87; 0.76–0.99). Poor EQI, mostly reflected by poor water quality, was associated with increased odds of EoE, while poor air and land quality were inversely associated with EoE. Additional work to identify specific water pollutants that may have an etiologic role in EoE may be warranted.