Prevalence and characterization of frailty, depression, and cognitive impairment in patients listed for heart transplantation: Results of the FELICITAR prospective registry

• Published in: Clinical transplantation 2021-09, Vol.35 (9), p.e14391-n/a
• Main Authors: Ayesta, Ana, Valero Masa, María Jesús, Vidán, María Teresa, Luna‐López, Raquel, Segovia‐Cubero, Javier, García‐Cosío, María Dolores, Pérez Gómez, Laura, Pérez, Pedro Caravaca, Vázquez López‐ Ibor, Jorge, Nuche, Jorge, Martínez‐Sellés, Manuel
• Format: Article
• Language: English
• Subjects: depression; frailty; hand grip strength; heart transplantation
• ISSN: 0902-0063; 1399-0012
• DOI: 10.1111/ctr.14391

Introduction It is recommended to assess frailty prior to heart transplantation (HT). Our objective was to assess the prevalence of frailty in patients listed for HT. Methods The FELICITAR registry (Frailty Evaluation after List Inclusion, Characteristics and Influence on TrAnsplantation And Results) is a prospective registry that includes patients listed for HT in three centers, from January 2017 to April 2019. We assessed the presence of frailty, depression, cognitive impairment, and quality of life when included. Results Ninety‐nine patients were included. Of this group, 30.6% were frail, 55 (56.1%) had depression (treated only in nine patients), and 51 (54.8%) had cognitive impairment. Compared with non‐frail patients, frail patients were more frequently hospitalized when included in HT waiting list (P = .048), had a lower upper‐arm circumference (P = .026), had a lower Barthel index (P = .001), more anemia (P = .010), higher rates of depression (P = .001), poorer quality of life (P = .001), and lower hand‐grip strength (P