3D-printed composite, calcium silicate ceramic doped with CaSO4·2H2O: Degradation performance and biocompatibility

• Published in: Journal of the mechanical behavior of biomedical materials 2021-09, Vol.121, p.104642-104642, Article 104642
• Main Authors: Zhang, Hanxu, Jiao, Chen, Liu, Zibo, He, Zhijing, Mengxing Ge, Zongjun Tian, Wang, Changjiang, Wei, Zhen, Shen, Lida, Liang, Huixin
• Format: Article
• Language: English
• Subjects: Biocompatibility; Biodegradability; Bone scaffolds; Calcium silicate
• ISSN: 1751-6161; 1878-0180
• DOI: 10.1016/j.jmbbm.2021.104642

Calcium silicate is a common implant material with excellent mechanical strength and good biological activity. In recent years, the addition of strengthening materials to calcium silicate has been proven to promote bone tissue regeneration, but its degradation properties require further improvements. In this paper, calcium silicate was used as the matrix, and 10 wt% hydroxyapatite and 10 wt% strontium phosphate were added to im prove the biological activity of the scaffold. The effect of adding different amounts of calcium sulfate dihydrate (CaSO4·2H2O) on the degradation of the scaffold was explored. A porous ceramic scaffold was prepared by digital light processing (DLP) technology, and its performance was evaluated. Cell experiments showed that the addition of calcium sulfate improved cell proliferation and differentiation. Simulated body fluid (SBF) immersion tests showed that small amounts of apatite deposits appeared on the fourth day, larger deposits appeared on the 14th day, and degradation occurred on the surface after 28 days of immersion. Mechanical tests showed that the addition of 5 wt% CaSO4·2H2O improved the compressibility of the composite. After soaking in SBF for 14 days, it retained its compressive strength (11.8 MPa), which meets the requirements of cancellous bone, demonstrating its potential application value for bone repair.