Novel insights into the genetically obese (ob/ob) and diabetic (db/db) mice: two sides of the same coin

Background Leptin-deficient ob/ob mice and leptin receptor-deficient db/db mice are commonly used mice models mimicking the conditions of obesity and type 2 diabetes development. However, although ob/ob and db/db mice are similarly gaining weight and developing massive obesity, db/db mice are more d...

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Bibliographic Details
Published in:	Microbiome 2021-06, Vol.9 (1), p.1-20, Article 147
Main Authors:	Suriano, Francesco, Vieira-Silva, Sara, Falony, Gwen, Roumain, Martin, Paquot, Adrien, Pelicaen, Rudy, Régnier, Marion, Delzenne, Nathalie M., Raes, Jeroen, Muccioli, Giulio G., Van Hul, Matthias, Cani, Patrice D.
Format:	Article
Language:	English
Subjects:	Adipose tissue Animal models Bile acids Bioinformatics Biomedical and Life Sciences Biomedicine Body fat Body weight Cecum db/db Diabetes Diabetes mellitus (non-insulin dependent) Energy Fatty acids Fatty liver Feces Genotypes Glucose Glucose metabolism Inflammation Insulin Insulin resistance Insulin secretion Intestinal microflora Laboratory animals Leptin-deficiency Leptin-receptor deficiency Lipopolysaccharides Liver Medical Microbiology Metabolic disorders Metabolites Microbial Ecology Microbial Genetics and Genomics Microbiology Microbiota Mimicry Mutation NMR Nuclear magnetic resonance ob/ob Obesity Phenotypes Steatosis Virology
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