A Serum Resistin and Multicytokine Inflammatory Pathway Is Linked With and Helps Predict All-cause Death in Diabetes

Abstract Context Type 2 diabetes (T2D) shows a high mortality rate, partly mediated by atherosclerotic plaque instability. Discovering novel biomarkers may help identify high-risk patients who would benefit from more aggressive and specific managements. We recently described a serum resistin and mul...

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Published in:The journal of clinical endocrinology and metabolism 2021-11, Vol.106 (11), p.e4350-e4359
Main Authors: Scarale, Maria Giovanna, Antonucci, Alessandra, Cardellini, Marina, Copetti, Massimiliano, Salvemini, Lucia, Menghini, Rossella, Mazza, Tommaso, Casagrande, Viviana, Ferrazza, Gianluigi, Lamacchia, Olga, De Cosmo, Salvatore, Di Paola, Rosa, Federici, Massimo, Trischitta, Vincenzo, Menzaghi, Claudia
Format: Article
Language:English
Subjects:
Analysis
Arteriosclerosis
Atherosclerosis
Cardiovascular diseases
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetics
Health aspects
Inflammation
Interleukin 6
Interleukins
Investigations
Medical research
Medicine, Experimental
Monoclonal antibodies
Mortality
Prediction models
Risk groups
Tumor necrosis factor
Tumor necrosis factor-α
Type 2 diabetes
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Summary:Abstract Context Type 2 diabetes (T2D) shows a high mortality rate, partly mediated by atherosclerotic plaque instability. Discovering novel biomarkers may help identify high-risk patients who would benefit from more aggressive and specific managements. We recently described a serum resistin and multicytokine inflammatory pathway (REMAP), including resistin, interleukin (IL)-1β, IL-6, IL-8, and TNF-α, that is associated with cardiovascular disease. Objective We investigated whether REMAP is associated with and improves the prediction of mortality in T2D. Methods A REMAP score was investigated in 3 cohorts comprising 1528 patients with T2D (409 incident deaths) and in 59 patients who underwent carotid endarterectomy (CEA; 24 deaths). Plaques were classified as unstable/stable according to the modified American Heart Association atherosclerosis classification. Results REMAP was associated with all-cause mortality in each cohort and in all 1528 individuals (fully adjusted hazard ratio [HR] for 1 SD increase = 1.34, P 
ISSN:0021-972X
1945-7197
DOI:10.1210/clinem/dgab472