Anorectal dose-effect relations for late gastrointestinal toxicity following external beam radiotherapy for prostate cancer in the FLAME trial

Highlights•A higher radiation dose to the anorectum is associated with increased overall GI toxicity following external beam radiotherapy for prostate cancer. •Increasing the dose to the anorectum should be carefully weighed against the benefit of focal dose escalation for prostate cancer and the an...

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Bibliographic Details
Published in:Radiotherapy and oncology 2021-09, Vol.162, p.98-104
Main Authors: Groen, Veerle H, Zuithoff, Nicolaas P.A, van Schie, Marcel, Monninkhof, Evelyn M, Kunze-Busch, Martina, de Boer, Hans C.J, van der Voort van Zyp, Jochem, Pos, Floris J, Smeenk, Robert Jan, Haustermans, Karin, Isebaert, Sofie, Draulans, Cédric, Depuydt, Tom, Verkooijen, Helena M, van der Heide, Uulke A, Kerkmeijer, Linda G.W
Format: Article
Language:English
Subjects:
Anorectal dose parameters
Brachytherapy
Clinical Protocols
Disease-Free Survival
Dose-effect relations
External beam radiotherapy
Focal boosting
Gastrointestinal Diseases - etiology
Gastrointestinal toxicity
Hematology, Oncology, and Palliative Medicine
Humans
Male
Prostate cancer
Prostatic Neoplasms - radiotherapy
Radiotherapy Dosage
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Summary:Highlights•A higher radiation dose to the anorectum is associated with increased overall GI toxicity following external beam radiotherapy for prostate cancer. •Increasing the dose to the anorectum should be carefully weighed against the benefit of focal dose escalation for prostate cancer and the anorectal dose constraints should be respected. •Further optimization of treatment plans, in order to increase the boost to the tumor without increasing the dose to the anorectum, should be explored.
ISSN:0167-8140
1879-0887
DOI:10.1016/j.radonc.2021.06.033