Ionic Covalent‐Organic Framework Nanozyme as Effective Cascade Catalyst against Bacterial Wound Infection

The increasing resistance risks of conventional antibiotic abuse and the formed biofilm on the surface of wounds have been demonstrated to be the main problems for bacteria‐caused infections and unsuccessful wound healing. Treatment by reactive oxygen species, such as the commercial H2O2, is a feasi...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2021-08, Vol.17 (32), p.e2100756-n/a
Main Authors: Li, Yite, Wang, Lei, Liu, Hao, Pan, Yong, Li, Chaonan, Xie, Zhigang, Jing, Xiabin
Format: Article
Language:English
Subjects:
antibacterial
Antibiotics
Antiinfectives and antibacterials
Bacteria
Biocompatibility
cascade reaction
Catalysts
covalent‐organic framework
Gluconic acid
Glucose
Glucose oxidase
Hydrogen peroxide
Hydroxyl radicals
Nanotechnology
nanozyme
Peroxidase
Side effects
Wound healing
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Summary:The increasing resistance risks of conventional antibiotic abuse and the formed biofilm on the surface of wounds have been demonstrated to be the main problems for bacteria‐caused infections and unsuccessful wound healing. Treatment by reactive oxygen species, such as the commercial H2O2, is a feasible way to solve those problems, but limits in its lower efficiency. Herein, an ionic covalent‐organic framework‐based nanozyme (GFeF) with self‐promoting antibacterial effect and good biocompatibility has been developed as glucose‐triggered cascade catalyst against bacterial wound infection. Besides the efficient conversion of glucose to hydrogen peroxide, the produced gluconic acid by loading glucose oxidase can supply a compatible catalytic environment to substantially improve the peroxidase activity for generating more toxic hydroxyl radicals. Meanwhile, the adhesion between the positively charged GFeF and the bacterial membrane can greatly enhance the healing effects. This glucose‐triggered cascade strategy can reduce the harmful side effects by indirectly producing H2O2, potentially used in the wound healing of diabetic patients. The hydrogel containing GFeF nanozymes is used to treat infected wounds with Staphylococcus aureus via cascade reaction. The hydrogen peroxide is produced by catalytic glucose, and converted to hydroxyl free radicals to kill bacteria at the wound site. This glucose‐triggered cascade strategy improves the sterilization efficiency and avoids damage to normal tissues.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.202100756