FKBP3 Induces Human Immunodeficiency Virus Type 1 Latency by Recruiting Histone Deacetylase 1/2 to the Viral Long Terminal Repeat

The primary reason why AIDS cannot be completely cured is the existence of a latent HIV-1 reservoir. Currently, the facts of HIV-1 latency, including its establishment and maintenance, are incomplete. Human immunodeficiency virus type 1 (HIV-1) cannot be completely eliminated because of existence of...

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Bibliographic Details
Published in:	mBio 2021-08, Vol.12 (4), p.e0079521
Main Authors:	Yang, Xinyi, Zhao, Xiaying, Zhu, Yuqi, Shen, Yinzhong, Wang, Yanan, Lu, Panpan, Jiang, Zhengtao, Pan, Hanyu, Yang, Jinlong, Xun, Jingna, Zhao, Lin, Wang, Jing, Liang, Zhiming, Shen, Xiaoting, Liang, Yue, Lin, Qinru, Liang, Huitong, Jin, Lu, Zhang, Dengji, Liu, Jun, Wang, Bin, Jiang, Shibo, Xu, Jianqing, Wu, Hao, Lu, Hongzhou, Zhu, Huanzhang
Format:	Article
Language:	English
Subjects:	acetylation Antibodies Antiretroviral drugs Cell Line Cell lines CRISPR Deacetylation Drug therapy Epigenesis, Genetic Epigenetics FKBP3 Gene Expression Regulation Genes Genetic screening HDAC1/2 Histone deacetylase Histone Deacetylase 1 - genetics Histone Deacetylase 1 - metabolism Histone Deacetylase 2 - genetics Histone Deacetylase 2 - metabolism HIV HIV Long Terminal Repeat - genetics HIV Long Terminal Repeat - physiology HIV-1 HIV-1 - genetics HIV-1 - physiology HIV-1 latency Host-Microbial Interactions Human immunodeficiency virus Humans Immune system Immunoregulation Jurkat Cells Latency Latent infection Long terminal repeat Medical research Protein Binding Protein folding Proteins Research Article Tacrolimus Binding Proteins - genetics Tacrolimus Binding Proteins - metabolism Transcription Factors - metabolism Virus Activation Virus Latency - genetics
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