Role of macrophages and phagocytes in orchestrating normal and pathologic hematopoietic niches

• Published in: Experimental hematology 2021-08, Vol.100, p.12-31.e1
• Main Authors: Lévesque, Jean-Pierre, Summers, Kim M., Millard, Susan M., Bisht, Kavita, Winkler, Ingrid G., Pettit, Allison R.
• Format: Article
• Language: English
• Subjects: Animals; Bone Marrow - pathology; Hematopoiesis; Hematopoietic Stem Cells - cytology; Hematopoietic Stem Cells - pathology; Humans; Lymphoma - pathology; Macrophages - cytology; Macrophages - pathology; Multiple Myeloma - pathology; Phagocytes - cytology; Phagocytes - pathology; Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology
• ISSN: 0301-472X; 1873-2399
• DOI: 10.1016/j.exphem.2021.07.001

•Phagocytes regulate HSCs and cells of their niche in the BM.•Phagocytes adapt hematopoiesis output to immune and inflammatory stressors.•Phagocytes regulate HSC retention and mobilization.•Abnormal macrophages alter niche function, promoting aplastic anemia or malignancies.•BM-Resident macrophages fragment, leading to misinterpretation of single-cell data. The bone marrow (BM) contains a mosaic of niches specialized in supporting different maturity stages of hematopoietic stem and progenitor cells such as hematopoietic stem cells and myeloid, lymphoid, and erythroid progenitors. Recent advances in BM imaging and conditional gene knockout mice have revealed that niches are a complex network of cells of mesenchymal, endothelial, neuronal, and hematopoietic origins, together with local physicochemical parameters. Within these complex structures, phagocytes, such as neutrophils, macrophages, and dendritic cells, all of which are of hematopoietic origin, have been found to be important in regulating several niches in the BM, including hematopoietic stem cell niches, erythropoietic niches, and niches involved in endosteal bone formation. There is also increasing evidence that these macrophages have an important role in adapting hematopoiesis, erythropoiesis, and bone formation in response to inflammatory stressors and play a key part in maintaining the integrity and function of these. Likewise, there is also accumulating evidence that subsets of monocytes, macrophages, and other phagocytes contribute to the progression and response to treatment of several lymphoid malignancies such as multiple myeloma, Hodgkin lymphoma, and non-Hodgkin lymphoma, as well as lymphoblastic leukemia, and may also play a role in myelodysplastic syndrome and myeloproliferative neoplasms associated with Noonan syndrome and aplastic anemia. In this review, the potential functions of macrophages and other phagocytes in normal and pathologic niches are discussed, as are the challenges in studying BM and other tissue-resident macrophages at the molecular level.