Intermolecular Interception of α‑Oxo Gold Carbenes of Nitroalkyne Cycloisomerization with 1,2-Benzo[d]isoxazole: Synthesis of Functionalized Quinazoline 1‑Oxides

The known nitrogen-transfer reagent 1,2-benzo­[d]­isoxazole has been used to trap the postulated α-oxo gold carbene intermediate involved in the [Au]-catalyzed internal redox process of 2-alkynylnitrobenzenes. This process led us to develop a general convergent method for the synthesis of highly fun...

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Bibliographic Details
Published in:Journal of organic chemistry 2021-08, Vol.86 (15), p.10874-10882
Main Authors: Dhote, Pawan S, Pund, Kishor A, Ramana, Chepuri V
Format: Article
Language:English
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Summary:The known nitrogen-transfer reagent 1,2-benzo­[d]­isoxazole has been used to trap the postulated α-oxo gold carbene intermediate involved in the [Au]-catalyzed internal redox process of 2-alkynylnitrobenzenes. This process led us to develop a general convergent method for the synthesis of highly functionalized quinazoline 1-oxides.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.1c01221