Giant cell tumor of thyroid cartilage: A diagnostic dilemma on aspiration cytology

Giant cell tumor of the larynx is an uncommon entity with only 44 cases reported in the literature. These tumors occur most commonly in the epiphysis of the long bones of female patients in third decade. Here in we report a case of 23 years old male patient who presented with an anterior neck swelli...

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Bibliographic Details
Published in:Diagnostic cytopathology 2021-11, Vol.49 (11), p.E423-E427
Main Authors: Anandani, Garima M., Yadav, Rajni, Verma, Hitesh, Jain, Deepali, Mathur, Sandeep, Iyer, Venkateswaran K.
Format: Article
Language:English
Subjects:
Cartilage
Cellular biology
Cytodiagnosis - methods
Diagnosis, Differential
giant cell tumor
Giant Cell Tumors - diagnosis
Giant Cell Tumors - pathology
Giant Cells - pathology
Humans
Laryngeal Neoplasms - pathology
Larynx
Male
thyroid cartilage
Thyroid Cartilage - pathology
Thyroid gland
Thyroid Neoplasms - diagnosis
Thyroid Neoplasms - pathology
Tumors
Young Adult
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Summary:Giant cell tumor of the larynx is an uncommon entity with only 44 cases reported in the literature. These tumors occur most commonly in the epiphysis of the long bones of female patients in third decade. Here in we report a case of 23 years old male patient who presented with an anterior neck swelling since past 4 months. Ultrasound and computed tomography of neck revealed a heterogenously enhancing lesion involving posteroinferior half of right thyroid cartilage with extension into the extra laryngeal strap muscle and intralaryngeal right true vocal cord and false vocal cord. The findings were suggestive of a neoplastic cartilagenous lesion. A fine needle aspiration of the right anterior neck mass was performed which showed many mononuclear cells along with multinucleated osteoclast type giant cells. No thyroid follicular cells or inflammatory cells were seen. A diagnosis of giant cell tumor of the thyroid cartilage was rendered on cytology. A biopsy was subsequently performed for the patient which confirmed the same. Hence, although giant cell tumor of the larynx is a rare entity, with very few cases reported in the literature, these tumors should be included in the differential diagnosis of giant cell lesions of the neck and aspiration cytology can offer an accurate and quick diagnosis in such cases.
ISSN:8755-1039
1097-0339
DOI:10.1002/dc.24845