Mitophagy in Huntington's disease

Huntington's disease (HD), as well as Parkinson's disease and Alzheimer's disease, belong to a group of neurodegenerative diseases characterized by common features, such as the progressive loss of neurons and the presence of pathogenic forms of misfolded protein aggregates. A quality...

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Bibliographic Details
Published in:Neurochemistry international 2021-10, Vol.149, p.105147-105147, Article 105147
Main Authors: Šonský, I., Vodička, P., Vodičková Kepková, K., Hansíková, H.
Format: Article
Language:English
Subjects:
Animals
Biological Products - therapeutic use
Humans
Huntingtin Protein - genetics
Huntingtin Protein - metabolism
Huntington Disease - drug therapy
Huntington Disease - genetics
Huntington Disease - metabolism
Huntington Disease - pathology
Huntington's disease
Mitochondria
Mitochondria - genetics
Mitochondria - metabolism
Mitochondria - pathology
Mitophagy
Mitophagy - physiology
Mitophagy adaptors
Neurons - metabolism
Neurons - pathology
Neuroprotective Agents - therapeutic use
Pharmacological induction of mitophagy
Protein Aggregates - physiology
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Summary:Huntington's disease (HD), as well as Parkinson's disease and Alzheimer's disease, belong to a group of neurodegenerative diseases characterized by common features, such as the progressive loss of neurons and the presence of pathogenic forms of misfolded protein aggregates. A quality control system such as autophagy is crucial for the clearance of protein aggregates and dysfunctional organelles and thus essential for the maintenance of neuronal homeostasis. The constant high energy demand of neuronal tissue links neurodegeneration to mitochondria. Inefficient removal of damaged mitochondria is thought to contribute to the pathogenesis of neurodegenerative diseases such as HD. In addition, direct involvement of the huntingtin protein in the autophagic machinery has been described. In this review, we focus on mitophagy, a selective form of autophagy responsible for mitochondrial turnover. We also discuss the relevance of pharmacological regulation of mitophagy in the future therapeutic approach to neurodegenerations, including HD. •Mitophagy is responsible for the turnover of mitochondria•Mitochondrial Quality Control in HD is impaired•Dysfunctional mitochondrial turnover may contribute to the pathogenesis of HD•Mitophagy is target of possible therapy in neurodegenerative diseases
ISSN:0197-0186
1872-9754
DOI:10.1016/j.neuint.2021.105147