Preclinical mouse model of optical coherence tomography for subcortical brain imaging without dissection

The purpose of this study was to investigate the feasibility of using optical coherence tomography (OCT) to identify internal brain lesions, specifically intracerebral hemorrhage, without dissection. Mice with artificially injected brain hematomas were used to test the OCT system, and the recorded i...

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Bibliographic Details
Published in:Journal of biophotonics 2021-11, Vol.14 (11), p.e202100143-n/a
Main Authors: Lee, Jae Meen, Han, Inho, Nam, Kyoung Hyup, Kim, Dong Hwan, Song, Seunghwan, Park, Heejeong, Kim, Hongki, Kim, Minkyu, Choi, Jeonghun, Lee, Jae Il
Format: Article
Language:English
Subjects:
Animals
Brain
Brain - diagnostic imaging
Dissection
Hematoma
Hemorrhage
intracerebral hematoma
Lesions
Medical imaging
Mice
Mouse devices
Neuroimaging
neurosurgery
Optical Coherence Tomography
Tomography
Tomography, Optical Coherence
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Description
Summary:The purpose of this study was to investigate the feasibility of using optical coherence tomography (OCT) to identify internal brain lesions, specifically intracerebral hemorrhage, without dissection. Mice with artificially injected brain hematomas were used to test the OCT system, and the recorded images were compared with microscopic images of the same mouse brains after hematoxylin and eosin staining. The intracranial structures surrounding the hematomas were clearly visualized by the OCT system without dissection. These images reflect the ability of OCT to determine the extent of a lesion in several planes. OCT is a useful technology, and these findings could be used as a starting point for future research in intraoperative imaging. The purpose of this study was to investigate the feasibility of using optical coherence tomography (OCT) to identify internal mice brain lesions, injected hemorrhage, in several planes without dissection. After our experiments, OCT is a useful technology, and these findings could be used as a starting point for future research in intraoperative imaging.
ISSN:1864-063X
1864-0648
DOI:10.1002/jbio.202100143