Hepatic lesions in captive owl monkeys (Aotus infulatus) with ultrasonographic “starry sky” liver

Background The “starry sky” (SK) liver is ultrasonographic pattern characterized by multiple hyperechogenic foci in hepatic parenchyma. The study aimed to characterize the microscopic hepatic lesions in captive owl monkeys with SK liver. Methods Thirty‐seven clinically healthy owl monkeys had their...

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Bibliographic Details
Published in:Journal of medical primatology 2021-10, Vol.50 (5), p.240-248
Main Authors: de Souza, Alex Junior Souza, Coutinho, Leandro Nassar, Silva, Wellington Bandeira da, Imbeloni, Aline Amaral, Carneiro, Liliane Almeida, Kanashiro‐Galo, Luciane, Hagen, Stefano Carlo Filippo, Malheiros, Andreza Pinheiro, Sá, Lilian Rose Marques de
Format: Article
Language:English
Subjects:
Bartonella
Bartonella spp
Biopsy
Degeneration
granuloma
Granulomas
Granulomatous hepatitis
Hemosiderosis
Hepatitis
Lesions
Liver
nonhuman primates
Parenchyma
Peliosis hepatis
Steatosis
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Summary:Background The “starry sky” (SK) liver is ultrasonographic pattern characterized by multiple hyperechogenic foci in hepatic parenchyma. The study aimed to characterize the microscopic hepatic lesions in captive owl monkeys with SK liver. Methods Thirty‐seven clinically healthy owl monkeys had their liver scanned and 18 of them had liver biopsy. Animals with SK and peliosis hepatis (PH) were subjected to immunohistochemical and molecular screening for Bartonella spp. Results SK liver occurred in 59.4% (22/37) of the owl monkeys. Biopsied animals showed steatosis, hydropic degeneration, hemosiderosis, PH, and multifocal granulomatous hepatitis. Two monkeys had SK, granulomatous hepatitis, and PH which were negative for Bartonella spp. Conclusions PH and granulomatous hepatitis associated with hepatocellular degenerative lesions may present as hyperechoic nodular liver lesions consisted of SK liver; therefore, concomitant occurrence of two lesions or more contributed to the hepatic SK pattern among owl monkeys and such cases might be clinically monitored.
ISSN:0047-2565
1600-0684
DOI:10.1111/jmp.12535