Oxidative bursts of single mitochondria mediate retrograde signaling toward the ER

The emerging role of mitochondria as signaling organelles raises the question of whether individual mitochondria can initiate heterotypic communication with neighboring organelles. Using fluorescent probes targeted to the endoplasmic-reticulum-mitochondrial interface, we demonstrate that single mito...

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Bibliographic Details
Published in:Molecular cell 2021-09, Vol.81 (18), p.3866-3876.e2
Main Authors: Booth, David M., Várnai, Péter, Joseph, Suresh K., Hajnóczky, György
Format: Article
Language:English
Subjects:
apoptosis
Ca2+ microdomain
calcium
fluorescence
Inositol-1,4,5-trisphosphate receptor
inositols
mitochondria
Mitochondrial retrograde signaling
Organelle contacts
permeability
Redox nanodomain
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