Solvent-directed formation of helically twisted stacking constructs via self-assembly of tris(phenylisoxazolyl)benzene dimers

Ureido-pyrimidinone (UPy)-appended tris(phenylisoxazolyl)benzenes were synthesized. The UPy moieties of the tris(phenylisoxazolyl)benzenes stably formed self-complementary dimers in solution. The dimers self-assembled to form helically twisted stacking constructs in a process driven by π–π stacking...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2021-09, Vol.19 (33), p.7165-7171
Main Authors: Ono, Yudai, Hirao, Takehiro, Haino, Takeharu
Format: Article
Language:English
Subjects:
Absorption spectra
Benzene
Chloroform
Circular dichroism
Circular polarization
Dichroism
Dimers
Dipole interactions
Methylcyclohexane
Mixing ratio
Self-assembly
Stacking
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Summary:Ureido-pyrimidinone (UPy)-appended tris(phenylisoxazolyl)benzenes were synthesized. The UPy moieties of the tris(phenylisoxazolyl)benzenes stably formed self-complementary dimers in solution. The dimers self-assembled to form helically twisted stacking constructs in a process driven by π–π stacking interactions of UPy dimer moieties and dipole–dipole interactions of isoxazole units. Strong association affinity was seen within the stacking constructs compared with the previously reported isoxazole derivatives owing to the auxiliary π–π stacking interaction. Notably, tris(phenylisoxazolyl)benzenes showed an environmentally responsive nature. The absorption bands, emission intensities, and sizes of ensembles depended significantly on the mixing ratio of CHCl 3 and methylcyclohexane (MCH). Additionally, sharp on–off switching phenomena were seen in their circular dichroism (CD) and circularly polarized luminescence (CPL) spectra in response to the mixing ratio of CHCl 3 and MCH. CD and CPL were activated only at a certain mixing ratio of CHCl 3 /MCH, thus showing potential for the creation of molecular sensors.
ISSN:1477-0520
1477-0539
DOI:10.1039/d1ob01277k