One‐Pot Approach to Fe2+/Fe3+‐Based MOFs with Enhanced Catalytic Activity for Fenton Reaction

• Published in: Advanced healthcare materials 2021-10, Vol.10 (19), p.e2100780-n/a
• Main Authors: Meng, Xin, Zhang, Fan, Guo, Huanling, Zhang, Chunyang, Hu, Hangtong, Wang, Wei, Liu, Jie, Shuai, Xintao, Cao, Zhong
• Format: Article
• Language: English
• Subjects: Biodegradability; Catalytic activity; dual‐modality imaging; Fenton reaction; Glucose oxidase; Hydrogen peroxide; In vivo methods and tests; Iron; Magnetic resonance imaging; Metal-organic frameworks; Reactive oxygen species; Reagents; Side effects; starvation therapy; Tumor microenvironment; tumor microenvironment responsiveness; Tumors
• ISSN: 2192-2640; 2192-2659
• DOI: 10.1002/adhm.202100780

Smart theragnostic nanoplatforms exhibit great promise in clinical tumor treatment. The Fe‐based Fenton reaction in tumor sites may generate reactive oxygen species to kill cancer cells with negligible side effects on normal tissues. However, its efficiency and duration are limited by the low intracellular concentration of H2O2, weak acidicity of tumor tissue, and low catalytic activity of conventional Fenton reagents. Herein, a facile strategy is proposed to efficiently overcome these obstacles. An efficient enzymatic/Fenton‐starvation nanoreactor PMs loaded with glucose oxidase and perfluoropentane (PGPMs) is constructed through synthesizing methoxy‐PEG‐carboxymethy‐modified iron (Fe2+/Fe3+)‐based metal–organic frameworks (PMs), followed by loading glucose oxidase (GOx) and perfluoropentane (PFP). PGPMs accumulating in the tumor tissue exhibit tumor microenvironment‐responsive biodegradable behavior and unusual catalytic activity for Fenton reaction advantageous over Fe3+‐based MOFs. Meanwhile, encapsulation of GOx into PGPMs further significantly increases the catalytic activity for Fenton reaction and also induces starvation therapy. PGPMs also exhibit considerable capabilities of ultrasound and tumor microenvironment‐responsive T2 MR imaging applicable for contrast‐enhanced diagnosis. Both in vitro and in vivo studies demonstrate the great diagnostic and therapeutic potentials of this nanoreactor in tumor. A tumor microenvironment‐responsive nanodrug is developed based on glucose oxidase/perfluoropentane loaded nanosized metal–organic frameworks (Fe2+/Fe3+) for effective enzymatic/Fenton therapy and starvation therapy under the guidance of ultrasound imaging and enhanced T2 MR imaging.