Is pseudoexfoliation syndrome associated with vitreoretinal interface abnormalities?

Background To evaluate vitreoretinal interface abnormalities in patients with pseudoexfoliation (PEX) syndrome. Methods This case–control study was performed in 136 patients diagnosed with unilateral PEX (PEX group) and 139 age- and sex-matched healthy volunteers (Control group). Both the affected a...

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Bibliographic Details
Published in:Graefe's archive for clinical and experimental ophthalmology 2022-02, Vol.260 (2), p.431-437
Main Authors: Adıyeke, Seda Karaca, Kutlu, Neslisah, Özen, Kıvanç, Doran, Mehmet Ali, Demirbaş, Kemal, Ture, Gamze, Talay, Ekrem
Format: Article
Language:English
Subjects:
Age
Archives & records
Case-Control Studies
Endothelium
Epiretinal Membrane - complications
Epiretinal Membrane - diagnosis
Exfoliation Syndrome - complications
Exfoliation Syndrome - diagnosis
Exfoliation Syndrome - epidemiology
Humans
Medicine
Medicine & Public Health
Ophthalmology
Optic nerve
Optics
Retina
Retinal Disorders
Statistical analysis
Tomography
Tomography, Optical Coherence
Vitreous Detachment - complications
Vitreous Detachment - diagnosis
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Summary:Background To evaluate vitreoretinal interface abnormalities in patients with pseudoexfoliation (PEX) syndrome. Methods This case–control study was performed in 136 patients diagnosed with unilateral PEX (PEX group) and 139 age- and sex-matched healthy volunteers (Control group). Both the affected and contralateral eyes were evaluated in the PEX group and the right eye was evaluated in the Control group. Vitreoretinal interface abnormalities and posterior vitreous detachment (PVD) were evaluated on optical coherence tomography (OCT) examination. Results The incidences of incomplete and complete PVD were significantly higher in the affected than contralateral eye in the PEX group and in the right eye in the Control group ( P  = 0.009, P  = 0.012 and P  = 0.004, P  = 0.017, respectively). The rates of ‘no PVD’ were significantly higher in the contralateral eye in the PEX group and the Control group compared to the affected eye in the PEX group ( P  = 0.003 and P  = 0.001, respectively). The odds ratio for incomplete PVD was 3.1 in PEX eyes compared to the contralateral eye in the PEX group and 3.9 compared to the Control group. The rate of epiretinal membranes (ERMs) in the affected eye was significantly different from the contralateral eye in the PEX and Control groups ( P  
ISSN:0721-832X
1435-702X
DOI:10.1007/s00417-021-05373-z