Head and neck squamous cell carcinomas among males of the three largest Asian diasporas in the US, 2004–2013

•Asian groups more likely to have the diagnosis at a younger age.•South Asians had a greater proportion of oral cavity cancers.•Chinese and Filipinos had a greater proportion of non-oropharyngeal cancers.•Cases doubled among South Asians largely due to increase in oral cavity cancers.•Policy changes...

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Bibliographic Details
Published in:Cancer epidemiology 2021-10, Vol.74, p.102011-102011, Article 102011
Main Authors: Khosla, Shaveta, Hershow, Ronald C., Freels, Sally, Jefferson, Gina D., Davis, Faith G., Peterson, Caryn E.
Format: Article
Language:English
Subjects:
Asian people
Asians
Cancer
Comorbidity
Diagnosis
Diaspora
Epidemiology
Ethnicity
Family income
Head & neck cancer
Head and neck cancer
Head and neck carcinoma
Human papillomavirus
Laryngeal cancer
Males
Minority & ethnic groups
Nasopharyngeal cancer
Oral cancer
Oral carcinoma
Oral cavity
Oropharyngeal cancer
Population
Race
Risk analysis
Risk factors
Screening
Squamous cell carcinoma
Subgroups
Throat cancer
Trends
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Summary:•Asian groups more likely to have the diagnosis at a younger age.•South Asians had a greater proportion of oral cavity cancers.•Chinese and Filipinos had a greater proportion of non-oropharyngeal cancers.•Cases doubled among South Asians largely due to increase in oral cavity cancers.•Policy changes needed to promote screening and discourage high-risk habits. Head and neck squamous cell carcinomas (HNSCC) have not been fully examined in the Asian diasporas in the US, despite certain Asian countries having the highest incidence of specific HNSCCs. National Cancer Database was used to compare 1046 Chinese, 887 South Asian (Indian/Pakistani), and 499 Filipino males to 156,927 Non-Hispanic White (NHW) males diagnosed with HNSCC between 2004−2013. Multinomial logistic regression was used to assess the association of race/ethnicity with two outcomes – site group and late-stage diagnosis. Temporal trends were explored for site groups and subsites. South Asians had a greater proportion of oral cavity cancer [OCC] compared to NHWs (59 % vs. 25 %; ORadj =7.3 (95 % CI: 5.9–9.0)). In contrast, Chinese (64 % vs. 9%; ORadj =34.0 (95 % CI: 26.5–43.6)) and Filipinos (47 % vs. 9%; ORadj =10.0 (95 % CI: 7.8–12.9)) had a greater proportion of non-oropharyngeal cancer compared to NHWs. All three Asian subgroups had a higher likelihood of being diagnosed by age 40 (14 % Chinese, 10 % South Asian and 8% Filipino compared to 3% in NHW; p 
ISSN:1877-7821
1877-783X
DOI:10.1016/j.canep.2021.102011