Nonalcoholic fatty liver disease increases the risk of diabetes in young adults: A nationwide population-based study in Korea

Nonalcoholic fatty liver disease (NAFLD) is associated with an increased risk of diabetes but has been rarely investigated in young adults. In this study, we investigated the relationship between NAFLD and incident diabetes risk in young adults using nationwide Korean population data. This populatio...

Full description

Saved in:
Bibliographic Details
Published in:Metabolism, clinical and experimental clinical and experimental, 2021-10, Vol.123, p.154866-154866, Article 154866
Main Authors: Chung, Goh Eun, Cho, Eun Ju, Yoon, Ji Won, Yoo, Jeong-Ju, Chang, Young, Cho, Yuri, Park, Sang-Hyun, Han, Kyungdo, Shin, Dong Wook, Yu, Su Jong
Format: Article
Language:English
Subjects:
Adult
Cohort Studies
Diabetes
Diabetes Complications
Diabetes Mellitus - epidemiology
Female
Humans
Male
Non-alcoholic Fatty Liver Disease - complications
Population Surveillance
Republic of Korea - epidemiology
Risk
Risk Factors
Steatosis
Young adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Nonalcoholic fatty liver disease (NAFLD) is associated with an increased risk of diabetes but has been rarely investigated in young adults. In this study, we investigated the relationship between NAFLD and incident diabetes risk in young adults using nationwide Korean population data. This population-based cohort study from the Korean National Health Insurance Service included adults aged 20 through 39 years who underwent a health examination from 2009 to 2012. NAFLD was defined as a fatty liver index (FLI) ≥60 in the absence of alcohol consumption of ≥30 g/day. Newly diagnosed diabetes during follow-up was identified using claims data. Cox regression was used to calculate the hazard ratio for incident diabetes after adjusting for classical confounders. Among the 5,254,786 participants, 9.3% had an FLI ≥60. During the median follow-up of 8.6 years, 91,885 cases of incident diabetes occurred. In multivariable analysis, the risk of incident diabetes was significantly higher in the NAFLD group than the control group (adjusted hazard ratio = 4.97, 95% confidence interval, 4.90–5.05). Stratified analyses showed higher associations in those who were ≥30 years, male, obese, smokers, alcohol consumers, and did not regularly exercise (all P 
ISSN:0026-0495
1532-8600
DOI:10.1016/j.metabol.2021.154866